{"doi":"10.1111/ijpo.12921","title":"Associations between maternal obesity and offspring gut microbiome in the first year of life","abstract":"BACKGROUND: Maternal obesity is an important determinant of offspring obesity risk, which may be mediated via changes in the infant microbiome. OBJECTIVES: We examined infant faecal microbiome, short-chain fatty acids (SCFA), and maternal human milk oligosaccharides (HMO) in mothers with overweight/obese body mass index (BMI) (OW) compared with normal weight (NW) (Clinicaltrials.gov NCT01131117). METHODS: Infant stool samples at 1, 6, and 12 months were analysed by 16S rRNA sequencing. Maternal (BODPOD) and infant (quantitative nuclear magnetic resonance [QMR]) adiposity were measured. HMOs at 2 months postpartum and faecal SCFAs at 1 month were also assessed. Statistical analyses included multivariable and mixed linear models for assessment of microbiome diversity, composition, and associations of taxonomic abundance with metabolic and anthropometric variables. RESULTS: At 1 month, offspring of women with obesity had lower abundance of SCFA-producing bacteria (including Ruminococcus and Turicibacter) and lower faecal butyric acid levels. Lachnospiraceae abundance was lower in OW group at 6 months, and infant fat mass was negatively associated with the levels of Sutterella. Gradient boosting machine models indicated that higher α-diversity and specific microbial taxa at 1 month predicted elevated adiposity at 12 months with overall accuracy of 76.5%. Associations between maternal HMO concentrations and infant bacterial taxa differed between NW and OW groups. CONCLUSIONS: Elevated maternal BMI is associated with relative depletion of butyrate-producing microbes and faecal butyrate in the early infant faecal microbiome. Overall microbial richness may aid in prediction of elevated adiposity in later infancy.","journal":"Pediatric Obesity","year":2022,"id":239473,"datarank":1.275620783896555,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.688817333082333,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.688817333082333,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":41,"citers_with_citation_signal":34,"citers_with_endowment":34,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8343,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01131117"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":776299,"name":"Meghan L. Ruebel","orcid":"0000-0003-4303-1491","position":1,"is_corresponding":false},{"id":294362,"name":"Clark Sims","orcid":"0000-0003-2730-7283","position":2,"is_corresponding":false},{"id":865105,"name":"Ying Zhong","orcid":"0000-0002-8498-1373","position":3,"is_corresponding":false},{"id":296550,"name":"Donald Turner","orcid":null,"position":4,"is_corresponding":false},{"id":488292,"name":"Renny S. Lan","orcid":"0000-0001-8346-043X","position":5,"is_corresponding":false},{"id":273742,"name":"Lindsay Pack","orcid":"0009-0005-1277-602X","position":6,"is_corresponding":false},{"id":273738,"name":"Brian D. Piccolo","orcid":"0000-0002-1789-4587","position":7,"is_corresponding":false},{"id":273739,"name":"Sree V. Chintapalli","orcid":"0000-0001-8457-9643","position":8,"is_corresponding":false},{"id":515213,"name":"Ann Abraham","orcid":"0000-0001-6941-7603","position":9,"is_corresponding":false},{"id":240567,"name":"Lars Bode","orcid":"0000-0002-9914-9571","position":10,"is_corresponding":false},{"id":273746,"name":"Aline Andres","orcid":"0000-0003-2611-2193","position":11,"is_corresponding":false},{"id":273744,"name":"Kartik Shankar","orcid":"0000-0002-7964-9026","position":12,"is_corresponding":false},{"id":865104,"name":"Stephanie P. Gilley","orcid":"0000-0003-0304-5514","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:22:36.865157Z","pmid":"35478493","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}