{"doi":"10.1111/ijpo.12903","title":"Novel clinical algorithm for hypothalamic obesity in youth with brain tumours and factors associated with excess weight gain","abstract":"BACKGROUND: A standardized approach for identifying and treating hypothalamic obesity (HO) in children with hypothalamic tumours is lacking. OBJECTIVES: To describe children with hypothalamic tumours at risk for obesity, assess outcomes of a novel HO clinical algorithm, and identify factors associated with weight gain. METHODS: Retrospective analysis of youth with hypothalamic and suprasellar tumours, seen at a paediatric tertiary care centre from 2010 to 2020. RESULTS: The study cohort (n = 130, 50% female, median age at diagnosis 5 [range 0-17]y) had a median duration of follow up of 5 (0.03-17)y. At last recorded body mass index (BMI) measurement, 34% had obesity, including 17% with severe obesity. Median onset of overweight and obesity after diagnosis was 6.2 (0.3-134) and 8.9 (0.7-65) months, respectively. After algorithm implementation (n = 13), the proportion that had an early dietitian visit (within 6 months) increased from 36% to 54%, (p = 0.498) and weight management referrals increased from 51% to 83% (p = 0.286). Higher BMI z-score at diagnosis was associated with overweight and obesity development (p < 0.001). CONCLUSION: Patients with hypothalamic tumours commonly develop obesity. Use of a clinical algorithm may expedite recognition of HO. Further research is needed to identify predictors of weight gain and to develop effective treatment.","journal":"Pediatric Obesity","year":2022,"id":289173,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8887,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334623,"name":"Cameron Severn","orcid":"0000-0001-9562-581X","position":1,"is_corresponding":false},{"id":254435,"name":"Laura Pyle","orcid":"0000-0001-5577-8221","position":2,"is_corresponding":false},{"id":132352,"name":"Kathleen Dorris","orcid":"0000-0003-0753-2176","position":3,"is_corresponding":false},{"id":235308,"name":"Christina Chambers","orcid":"0000-0003-4675-7722","position":4,"is_corresponding":false},{"id":970810,"name":"Debra Stiller","orcid":null,"position":5,"is_corresponding":false},{"id":132348,"name":"Todd Hankinson","orcid":"0000-0002-6288-9496","position":6,"is_corresponding":false},{"id":301419,"name":"Thomas H. Inge","orcid":"0000-0001-7782-1112","position":7,"is_corresponding":false},{"id":784992,"name":"Matthew Haemer","orcid":"0000-0003-1288-6083","position":8,"is_corresponding":false},{"id":318215,"name":"David M. Mirsky","orcid":"0000-0003-2162-515X","position":9,"is_corresponding":false},{"id":970362,"name":"Jaime M. Moore","orcid":"0000-0001-6385-8723","position":10,"is_corresponding":false},{"id":254437,"name":"Megan M. Kelsey","orcid":"0000-0002-0755-1951","position":11,"is_corresponding":false},{"id":731125,"name":"Amy Rydin","orcid":"0000-0003-2607-1950","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T00:30:18.766838Z","pmid":"35224874","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}