{"doi":"10.1111/his.14014","title":"The role of glutaminase in cancer","abstract":"<jats:p>Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with different morphological and molecular subtypes and responses to therapy, and breast cancer cells are known to rewire glutamine metabolism to support survival and proliferation. Glutaminase isoenzymes (GLS and GLS2) are key enzymes for glutamine metabolism. Interestingly, GLS and GLS2 have contrasting functions in tumorigenesis. In this review, we explore the role of glutaminase in cancer, primarily focusing on breast cancer, address the role played by oncogenes and tumour suppressor genes in regulating glutaminase, and discuss current therapeutic approaches to targeting 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Alfarsi","orcid":null,"position":2,"is_corresponding":false},{"id":112300,"name":"Emad A Rakha","orcid":null,"position":3,"is_corresponding":false},{"id":112301,"name":"Andrew R Green","orcid":"0000-0002-0488-5913","position":4,"is_corresponding":false},{"id":112302,"name":"Madeleine L Craze","orcid":null,"position":5,"is_corresponding":false},{"id":112297,"name":"Brendah K 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Hypoxia, and Metabolism","Epigenetics and DNA Methylation","RNA modifications and cancer","Medicine","Biology","Animals","Glutaminase","Humans","Neoplasms"],"mesh_terms":["Animals","Glutaminase","Humans","Neoplasms"],"keywords":["Glutaminase","Glutaminolysis","Glutamine","Breast cancer","Cancer","Carcinogenesis","Biology","Isozyme","Cancer research","Cancer cell","Enzyme","Disease","Suppressor","Medicine","Genetics","Biochemistry","Internal medicine","Metabolism","Subtypes"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.22723130.v1","title":"Additional file 1 of Imaging the metabolic reprograming of fatty acid synthesis pathway enables new diagnostic and therapeutic opportunity for breast cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22723130","title":"Additional file 1 of Imaging the metabolic reprograming of fatty acid synthesis pathway enables new diagnostic and 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