{"doi":"10.1111/head.12944","title":"Functional Neuroimaging in Migraine: Chances and Challenges","abstract":"<jats:p>Functional neuroimaging studies are an indispensable tool in headache research and have greatly contributed to our understanding of migraine pathophysiology. The past two decades have identified the brainstem as the target region of interest in migraine pathophysiology: Recent evidence suggests that certain areas of the central nervous system and especially the brainstem periodically change activity during different stages of the migraine cycle. Additionally, the number of resting‐state functional MRI studies in migraine has increased greatly in recent years. Three future trends in migraine neuroimaging can be identified: brainstem optimized functional imaging, longitudinal approaches tracking biological changes through the migraine cycle, and optimized resting‐state fMRI. Consequently, we face a lot of difficulties regarding image noise and artifacts, organizational details, and data interpretation. Optimized neuroimaging studies and new approaches will continue to greatly contribute to our pathophysiological understanding of migraine.</jats:p>","journal":"Headache: The Journal of Head and Face Pain","year":2016,"id":593068,"datarank":1.1868741193159387,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.6579200406235144,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.6579200406235144,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":24,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":878321,"name":"Arne May","orcid":"0000-0002-3499-1506","position":1,"is_corresponding":false},{"id":1517835,"name":"Laura H. Schulte","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Functional Neuroimaging in Migraine: Chances and Challenges","abstract":"<jats:p>Functional neuroimaging studies are an indispensable tool in headache research and have greatly contributed to our understanding of migraine pathophysiology. The past two decades have identified the brainstem as the target region of interest in migraine pathophysiology: Recent evidence suggests that certain areas of the central nervous system and especially the brainstem periodically change activity during different stages of the migraine cycle. Additionally, the number of resting‐state functional MRI studies in migraine has increased greatly in recent years. Three future trends in migraine neuroimaging can be identified: brainstem optimized functional imaging, longitudinal approaches tracking biological changes through the migraine cycle, and optimized resting‐state fMRI. Consequently, we face a lot of difficulties regarding image noise and artifacts, organizational details, and data interpretation. Optimized neuroimaging studies and new approaches will continue to greatly contribute to our pathophysiological understanding of migraine.</jats:p>","is_dataset_classified":null,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27654831","pmcid":null,"openalex_id":"https://openalex.org/W2526360900","authors":[],"funders":[{"funder_name":"7th Framework EU-project EuroHeadPain","grant_id":"#602633","title":null},{"funder_name":"European Commission","grant_id":"602633","title":"Mechanisms and Treatment of Migraine and its Chronification"}],"total_grants":2,"fwci":3.3367,"citation_percentile":0.92414661,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":5},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhead.12944","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/head.12944","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/head.12944","host_type":"publisher"},{"url":"https://headachejournal.onlinelibrary.wiley.com/doi/pdf/10.1111/head.12944","host_type":"publisher"},{"url":"https://doi.org/10.1111/head.12944","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27654831","host_type":"repository"},{"url":"https://dx.doi.org/10.1111/head.12944","host_type":""},{"url":"http://dx.doi.org/10.1111/head.12944","host_type":""}],"fields_of_study":["Migraine and Headache Studies","Functional Brain Connectivity Studies","Neural and Behavioral Psychology Studies","03 medical and health sciences","0302 clinical medicine","Brain","Functional Neuroimaging","Humans","Migraine Disorders","Neural Pathways"],"mesh_terms":["Brain","Humans","Migraine Disorders","Neural Pathways","Functional Neuroimaging"],"keywords":["Migraine","Neuroimaging","Functional neuroimaging","Neuroscience","Brainstem","Resting state fMRI","Functional imaging","Psychology","Medicine","Psychiatry","fMRI","Resting state","Pathophysiology","Networks","Bold","Migraine Disorders","Neural Pathways","Brain","Humans"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T17:00:41.072075Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}