{"doi":"10.1111/febs.70240","title":"Lysine demethylase <scp>4A</scp> is a centrosome‐associated protein required for centrosome integrity and genomic stability","abstract":"Centrosomes play a fundamental role in nucleating and organizing microtubules in the cell and are vital for faithful chromosome segregation and maintenance of genomic stability. Loss of structural or functional integrity of centrosomes causes genomic instability and is a driver of oncogenesis. Here we identify lysine demethylase 4A (KDM4A), an epigenetic 'eraser' of chromatin methyl marks, as a centrosome-localized protein, visualized at the nanometer-scale resolution. We additionally uncovered that KDM4A demethylase enzymatic activity is required to maintain centrosome homeostasis and integrity; a previously unknown functionality unlinked to altered expression of genes regulating centrosome number. We find that KDM4A interacts with and localizes to the centrosome in all stages of mitosis, where it maintains centrosome numbers and centriole engagement during mitosis. Loss of KDM4A results in supernumerary centrosomes and accrual of chromosome segregation errors including chromatin bridges and micronuclei, markers of genomic instability. In summary, these data highlight a previously unknown role for an epigenetic 'eraser' regulating centrosome integrity, mitotic fidelity, and genomic stability at the centrosome.","journal":"FEBS Journal","year":2025,"id":534576,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9608,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":876480,"name":"Xiaoli Wang","orcid":"0000-0002-7198-273X","position":1,"is_corresponding":false},{"id":768429,"name":"Richard I. Han","orcid":"0000-0002-8332-622X","position":2,"is_corresponding":false},{"id":1417173,"name":"Manga Motrapu","orcid":"0000-0001-9579-4066","position":3,"is_corresponding":false},{"id":233999,"name":"Ashley Boice","orcid":null,"position":4,"is_corresponding":false},{"id":1226138,"name":"Yuya Nakatani","orcid":"0000-0002-1289-3921","position":5,"is_corresponding":false},{"id":1329438,"name":"Sofía Vargas-Hernández","orcid":"0000-0002-8726-7298","position":6,"is_corresponding":false},{"id":1078836,"name":"Julia F. Love","orcid":"0000-0001-6642-6301","position":7,"is_corresponding":false},{"id":515620,"name":"Claude Chew","orcid":null,"position":8,"is_corresponding":false},{"id":271399,"name":"Sandra L. Grimm","orcid":"0000-0002-0682-3134","position":9,"is_corresponding":false},{"id":1027838,"name":"Dereck Mezquita","orcid":"0000-0002-9307-6762","position":10,"is_corresponding":false},{"id":327215,"name":"Frank M. Mason","orcid":"0000-0003-1338-494X","position":11,"is_corresponding":false},{"id":446148,"name":"Elisabeth D. Martínez","orcid":"0000-0003-1131-3689","position":12,"is_corresponding":false},{"id":63736,"name":"Cristian Coarfa","orcid":"0000-0002-4183-4939","position":13,"is_corresponding":false},{"id":1417174,"name":"Cheryl L. Walker","orcid":"0000-0001-5787-6423","position":14,"is_corresponding":false},{"id":344923,"name":"Anna‐Karin Gustavsson","orcid":"0000-0002-0980-1168","position":15,"is_corresponding":false},{"id":327217,"name":"Ruhee Dere","orcid":"0000-0002-1457-609X","position":16,"is_corresponding":false},{"id":777169,"name":"Pratim Chowdhury","orcid":"0009-0003-8051-6153","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:51:47.434742Z","pmid":"40875546","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}