{"doi":"10.1111/febs.12570","title":"The proto-oncogene<i>JUN</i>is a target of the heat shock transcription factor HSF1","abstract":null,"journal":"FEBS Journal","year":2013,"id":616547,"datarank":0.5289540786924243,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.0,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1589650,"name":"Yukio Ishikawa","orcid":null,"position":1,"is_corresponding":false},{"id":1589653,"name":"Azumi Ota","orcid":null,"position":2,"is_corresponding":false},{"id":142450,"name":"Hiroshi Sakurai","orcid":null,"position":3,"is_corresponding":false},{"id":1589647,"name":"Maki Sawai","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The proto-oncogene<i>JUN</i>is a target of the heat shock transcription factor HSF1","abstract":"The transcription factor activator protein-1 (AP-1) participates in many aspects of cell physiology, such as cellular proliferation, transformation, and death. AP-1 is a dimeric complex that primarily contains Jun and Fos family members. Here, we report that JUN is a target of heat shock transcription factor HSF1. HSF1 is the master regulator of genes encoding molecular chaperones, and is involved in cellular processes such as the stress response, cell differentiation, aging and carcinogenesis. In HeLa cells, JUN transcription was rapidly induced by heat treatment. We found that HSF1 bound to the JUN promoter and was necessary for its efficient response to heat shock. In heat-shocked cells, c-Jun-mediated gene expression was induced slowly following accumulation of c-Jun protein. Forced expression of active HSF1 in cells resulted in an increase in c-Jun expression and activation of c-Jun target genes. These results show that HSF1 regulates JUN expression, thereby modulating AP-1 activity.","is_dataset_classified":null,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24127737","pmcid":null,"openalex_id":"https://openalex.org/W2062841269","authors":[],"funders":[],"total_grants":0,"fwci":0.963,"citation_percentile":0.74374834,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":5},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.12570","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.12570","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ffebs.12570","host_type":"publisher"},{"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/febs.12570/fullpdf","host_type":"publisher"},{"url":"https://doi.org/10.1111/febs.12570","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24127737","host_type":"repository"}],"fields_of_study":["Heat shock proteins research","Endoplasmic Reticulum Stress and Disease","Viral Infectious Diseases and Gene Expression in Insects","Blotting, Western","Cell Proliferation","Chromatin Immunoprecipitation","Cyclin D1","DNA-Binding Proteins","Electrophoretic Mobility Shift Assay","Gene Expression Regulation, Neoplastic","HeLa Cells","Heat Shock Transcription Factors","Heat-Shock Response","Hot Temperature","Humans","Hyaluronan Receptors","Luciferases","Promoter Regions, Genetic","Proto-Oncogene Mas","Proto-Oncogene Proteins c-jun","RNA, Messenger","RNA, Small Interfering","Real-Time Polymerase Chain Reaction","Response Elements","Reverse Transcriptase Polymerase Chain Reaction","Transcription Factor AP-1","Transcription Factors"],"mesh_terms":["Heat Shock Transcription Factors","Proto-Oncogene Mas","DNA-Binding Proteins","Hot Temperature","HeLa Cells","Humans","Luciferases","Promoter Regions, Genetic","RNA, Messenger","Transcription Factors","Blotting, Western","Gene Expression Regulation, Neoplastic","Proto-Oncogene Proteins c-jun","Transcription Factor AP-1","Heat-Shock Response","Hyaluronan Receptors","Cyclin D1","Reverse Transcriptase Polymerase Chain Reaction","Response Elements","Electrophoretic Mobility Shift Assay","RNA, Small Interfering","Chromatin Immunoprecipitation","Cell Proliferation","Real-Time Polymerase Chain Reaction","Hela Cells"],"keywords":["HSF1","Heat shock factor","Transcription factor","Heat shock","Cell biology","Biology","Activator (genetics)","Heat shock protein","c-jun","Promoter","Transcription (linguistics)","HSPA12A","Gene expression","Molecular biology","Gene","Hsp70","Genetics","AP-1","cyclin D1","CD44"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T23:10:40.632029Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}