{"doi":"10.1111/evj.14298","title":"Drug library screening for putative antiviral compounds' discovery against equine arteritis virus","abstract":"enteroids monolayers on a 24-well plate were inoculated with ECoV and fixed at 72 hpi for electron microscopy (EM).Results: IHC analysis revealed that the generated equine intestinal enteroids contained various cell types expressed in the equine intestinal epithelium in vivo.RT-qPCR showed that the viral gene copy number had increased by more than 1000-fold at 72 hpi compared to 2 hpi in enteroids derived from any intestinal tissues.Virus particles were observed in the cytoplasm and on the cell membrane by EM.These results indicate that ECoV replicated substantially in equine intestinal enteroids.Main limitation: Intestinal enteroids were established from only one horse. Conclusion:Equine intestinal enteroids generated from the duodenum, jejunum, and ileum supported ECoV replication and may be a valuable tool for in vitro studies of ECoV.","journal":"Equine Veterinary Journal","year":2024,"id":503784,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9298,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1353562,"name":"Mirjana Antonijevic","orcid":"0000-0002-4722-0903","position":1,"is_corresponding":false},{"id":1354033,"name":"Gabrielle Bouet","orcid":null,"position":2,"is_corresponding":false},{"id":1354034,"name":"Delphine Froger","orcid":null,"position":3,"is_corresponding":false},{"id":1354035,"name":"Fanny Lecouturier","orcid":null,"position":4,"is_corresponding":false},{"id":1354036,"name":"Anthony Madeline","orcid":null,"position":5,"is_corresponding":false},{"id":373374,"name":"Hélène Munier‐Lehmann","orcid":"0000-0001-7579-8561","position":6,"is_corresponding":false},{"id":1353563,"name":"Stéphane Pronost","orcid":"0000-0002-2584-0933","position":7,"is_corresponding":false},{"id":637926,"name":"Pierre‐Olivier Vidalain","orcid":"0000-0003-3082-7407","position":8,"is_corresponding":false},{"id":1353564,"name":"Patrick Dallemagne","orcid":"0000-0002-4845-615X","position":9,"is_corresponding":false},{"id":1353565,"name":"José Carlos Valle‐Casuso","orcid":"0000-0002-9637-7085","position":10,"is_corresponding":false},{"id":1354032,"name":"Anne-Lise Pocheron","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:31.826282Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}