{"doi":"10.1111/epi.18603","title":"Common network related to hyperkinetic seizures revealed by functional lesion network mapping","abstract":"OBJECTIVE: This study aims to determine whether the anatomically heterogeneous lesions that cause hyperkinetic seizures (HKS) are connected to a common functional network. METHODS: We identified patients from the Beijing Tiantan-Fengtai Epilepsy Center with HKs as the primary ictal semiology. These included patients had focal seizure-onset zone, here referred to as a \"lesion.\" The network of brain regions functionally connected to each lesion was identified using whole-brain functional connectivity from a functional magnetic resonance imaging (fMRI) dataset of healthy participants (n = 1000). Network maps were overlapped to identify regions functionally connected to most lesions. Specificity was evaluated using a case-control design. Therapeutic relevance was assessed using a cohort that underwent deep brain stimulation to the anterior nucleus of the thalamus to improve seizure control. RESULTS: Lesion locations for patients with HKS (n = 50) and patients without HKS (n = 47 for automatisms; n = 53 for elementary motor signs) were included. Based on the lesion brain network, the most sensitive and specific region with HKS was the anterior cingulate cortex (ACC) (>90% overlap). Reversed connectivity patterns between the ACC and the whole brain encompassed most lesion locations that caused HKS (47/50, 94%). In addition, the functional connectivity between ACC and deep brain stimulation sites was associated with improved seizure control (r = .49, p < .01) in 27 patients with drug-resistant epilepsy. SIGNIFICANCE: These findings indicated that HKS might be a symptom of brain network disruption that resulted from lesions in various brain regions commonly connected to ACC, emphasizing the ACC as a potential target for therapeutic intervention in HKS.","journal":"Epilepsia","year":2025,"id":546694,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7768,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1201182,"name":"Yao Chen","orcid":"0000-0002-4998-5088","position":1,"is_corresponding":false},{"id":1438787,"name":"Jinping Xu","orcid":"0000-0001-9175-2598","position":2,"is_corresponding":false},{"id":232894,"name":"Ningfei Li","orcid":"0000-0003-3315-3591","position":3,"is_corresponding":false},{"id":52213,"name":"Wenhan Hu","orcid":"0000-0002-4068-9928","position":4,"is_corresponding":false},{"id":1438788,"name":"Xiu Wang","orcid":"0000-0002-4800-6706","position":5,"is_corresponding":false},{"id":1160353,"name":"Baotian Zhao","orcid":"0000-0003-0920-6825","position":6,"is_corresponding":false},{"id":52214,"name":"Jiajie Mo","orcid":"0000-0002-9721-1378","position":7,"is_corresponding":false},{"id":1438789,"name":"Zhong Zheng","orcid":"0000-0002-8175-698X","position":8,"is_corresponding":false},{"id":1438790,"name":"Xiaoqiu Shao","orcid":"0000-0001-5798-7115","position":9,"is_corresponding":false},{"id":318761,"name":"Jianguo Zhang","orcid":"0000-0002-0009-0574","position":10,"is_corresponding":false},{"id":232911,"name":"Andreas Horn","orcid":"0000-0002-0695-6025","position":11,"is_corresponding":false},{"id":1013161,"name":"Chao Zhang","orcid":"0000-0002-9989-6462","position":12,"is_corresponding":false},{"id":634971,"name":"Kai Zhang","orcid":"0000-0003-4237-3115","position":13,"is_corresponding":false},{"id":1438786,"name":"Bowen Yang","orcid":"0000-0001-5218-7805","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:53:36.567932Z","pmid":"40913519","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}