{"doi":"10.1111/epi.17715","title":"In‐hospital outcomes in patients with and without epilepsy diagnosed with <scp>COVID</scp>‐19—A cohort study","abstract":"OBJECTIVES: Coronavirus disease 2019 (COVID-19) is associated with mortality in persons with comorbidities. The aim of this study was to evaluate in-hospital outcomes in patients with COVID-19 with and without epilepsy. METHODS: We conducted a retrospective study of patients with COVID-19 admitted to a multicenter health system between March 15, 2020, and May 17, 2021. Patients with epilepsy were identified using a validated International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM)/ICD-10-CM case definition. Logistic regression models and Kaplan-Meier analyses were conducted for mortality and non-routine discharges (i.e., not discharged home). An ordinary least-squares regression model was fitted for length of stay (LOS). RESULTS: We identified 9833 people with COVID-19 including 334 with epilepsy. On univariate analysis, people with epilepsy had significantly higher ventilator use (37.70% vs 14.30%, p < .001), intensive care unit (ICU) admissions (39.20% vs 17.70%, p < .001) mortality rate (29.60% vs 19.90%, p < .001), and longer LOS (12 days vs 7 days, p < .001). and fewer were discharged home (29.64% vs 57.37%, p < .001). On multivariate analysis, only non-routine discharge (adjusted odds ratio [aOR] 2.70, 95% confidence interval [CI] 2.00-3.70; p < .001) and LOS (32.50% longer, 95% CI 22.20%-43.60%; p < .001) were significantly different. Factors associated with higher odds of mortality in epilepsy were older age (aOR 1.05, 95% CI 1.03-1.08; p < .001), ventilator support (aOR 7.18, 95% CI 3.12-16.48; p < .001), and higher Charlson comorbidity index (CCI) (aOR 1.18, 95% CI 1.04-1.34; p = .010). In epilepsy, admissions between August and December 2020 or January and May 2021 were associated with a lower odds of non-routine discharge and decreased LOS compared to admissions between March and July 2020, but this difference was not statistically significant. SIGNIFICANCE: People with COVID-19 who had epilepsy had a higher odds of non-routine discharge and longer LOS but not higher mortality. Older age (≥65), ventilator use, and higher CCI were associated with COVID-19 mortality in epilepsy. This suggests that older adults with epilepsy and multimorbidity are more vulnerable than those without and should be monitored closely in the setting of COVID-19.","journal":"Epilepsia","year":2023,"id":382197,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6418,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":988338,"name":"Grace Van Hyfte","orcid":"0009-0001-8791-2285","position":1,"is_corresponding":false},{"id":514865,"name":"Parul Agarwal","orcid":"0000-0002-7497-8162","position":2,"is_corresponding":false},{"id":495253,"name":"Leah J. 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Peschansky","orcid":"0000-0002-5096-4161","position":10,"is_corresponding":false},{"id":348147,"name":"Churl‐Su Kwon","orcid":"0000-0001-9904-2240","position":11,"is_corresponding":false},{"id":664957,"name":"Ariella Cohen","orcid":"0000-0002-7160-8369","position":12,"is_corresponding":false},{"id":1148411,"name":"Andy Ho Wing Chan","orcid":"0009-0002-5055-9470","position":13,"is_corresponding":false},{"id":468062,"name":"Mandip S. Dhamoon","orcid":"0000-0003-2402-4632","position":14,"is_corresponding":false},{"id":1148412,"name":"Pojen Deng","orcid":"0000-0002-3465-6599","position":15,"is_corresponding":false},{"id":1148413,"name":"Eveline Gutzwiller","orcid":"0000-0002-7537-7545","position":16,"is_corresponding":false},{"id":1148414,"name":"Qing Hao","orcid":"0000-0002-1503-2203","position":17,"is_corresponding":false},{"id":1148415,"name":"Celestine He","orcid":"0000-0002-0110-072X","position":18,"is_corresponding":false},{"id":1148757,"name":"Wilson D. Heredia Nunez","orcid":null,"position":19,"is_corresponding":false},{"id":450190,"name":"Britany Klenofsky","orcid":null,"position":20,"is_corresponding":false},{"id":830300,"name":"Hernan Nicolás Lemus","orcid":"0000-0003-2485-461X","position":21,"is_corresponding":false},{"id":883187,"name":"Lara Marcuse","orcid":"0000-0002-1494-7241","position":22,"is_corresponding":false},{"id":1148758,"name":"Mallory Roberts","orcid":null,"position":23,"is_corresponding":false},{"id":1036015,"name":"Emily Schorr","orcid":"0000-0001-6825-8604","position":24,"is_corresponding":false},{"id":916737,"name":"Anuradha Singh","orcid":"0000-0002-8145-1369","position":25,"is_corresponding":false},{"id":968457,"name":"Gabriela Tantillo","orcid":"0000-0002-7911-7900","position":26,"is_corresponding":false},{"id":916738,"name":"James Young","orcid":"0000-0001-9349-7519","position":27,"is_corresponding":false},{"id":329637,"name":"Priti Balchandani","orcid":"0000-0001-7709-5835","position":28,"is_corresponding":false},{"id":1148759,"name":"Joanne R. 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