{"doi":"10.1111/ene.16304","title":"Symptom‐based staging for logopenic variant primary progressive aphasia","abstract":"BACKGROUND AND PURPOSE: Logopenic variant primary progressive aphasia (lvPPA) is a major variant presentation of Alzheimer's disease (AD) that signals the importance of communication dysfunction across AD phenotypes. A clinical staging system is lacking for the evolution of AD-associated communication difficulties that could guide diagnosis and care planning. Our aim was to create a symptom-based staging scheme for lvPPA, identifying functional milestones relevant to the broader AD spectrum. METHODS: An international lvPPA caregiver cohort was surveyed on symptom development under an 'exploratory' survey (34 UK caregivers). Feedback from this survey informed the development of a 'consolidation' survey (27 UK, 10 Australian caregivers) in which caregivers were presented with six provisional clinical stages and feedback was analysed using a mixed-methods approach. RESULTS: Six clinical stages were endorsed. Early symptoms included word-finding difficulty, with loss of message comprehension and speech intelligibility signalling later-stage progression. Additionally, problems with hearing in noise, memory and route-finding were prominent early non-verbal symptoms. 'Milestone' symptoms were identified that anticipate daily-life functional transitions and care needs. CONCLUSIONS: This work introduces a new symptom-based staging scheme for lvPPA, and highlights milestone symptoms that could inform future clinical scales for anticipating and managing communication dysfunction across the AD spectrum.","journal":"European Journal of Neurology","year":2024,"id":429688,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":695186,"name":"Cathleen Taylor‐Rubin","orcid":"0000-0003-4236-7401","position":1,"is_corresponding":false},{"id":1030485,"name":"Beatrice Taylor","orcid":"0000-0002-3630-5047","position":2,"is_corresponding":false},{"id":1030486,"name":"Emma Harding","orcid":"0000-0001-9675-2335","position":3,"is_corresponding":false},{"id":695183,"name":"Aida Suárez‐González","orcid":"0000-0002-0904-1031","position":4,"is_corresponding":false},{"id":1030487,"name":"Jessica Jiang","orcid":"0000-0002-7074-3032","position":5,"is_corresponding":false},{"id":1030488,"name":"Laura Thompson","orcid":"0000-0003-4961-4284","position":6,"is_corresponding":false},{"id":1031323,"name":"Rachel Kingma","orcid":null,"position":7,"is_corresponding":false},{"id":1030489,"name":"Anthipa Chokesuwattanaskul","orcid":"0000-0001-7973-8267","position":8,"is_corresponding":false},{"id":1030490,"name":"Ffion Walker","orcid":"0000-0001-8409-7134","position":9,"is_corresponding":false},{"id":867951,"name":"Suzie Barker","orcid":null,"position":10,"is_corresponding":false},{"id":1030491,"name":"Emilie Brotherhood","orcid":"0000-0002-6244-7735","position":11,"is_corresponding":false},{"id":1030492,"name":"Claire Waddington","orcid":"0000-0001-7483-767X","position":12,"is_corresponding":false},{"id":1030493,"name":"Olivia Wood","orcid":"0000-0003-1626-4118","position":13,"is_corresponding":false},{"id":1030494,"name":"Nikki Zimmermann","orcid":"0000-0002-4710-5470","position":14,"is_corresponding":false},{"id":1030495,"name":"Nuriye Kupeli","orcid":"0000-0001-6511-412X","position":15,"is_corresponding":false},{"id":989170,"name":"Keir Yong","orcid":"0000-0002-9708-3599","position":16,"is_corresponding":false},{"id":1030496,"name":"Paul M. 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