{"doi":"10.1111/ene.15157","title":"Cerebellar pathology and disability worsening in relapsing‐remitting multiple sclerosis: A retrospective analysis from the CombiRx trial","abstract":"BACKGROUND AND PURPOSE: Cerebellar damage is a valuable predictor of disability, particularly in progressive multiple sclerosis. It is not clear if it could be an equally useful predictor of motor disability worsening in the relapsing-remitting phenotype. AIM: We aimed to determine whether cerebellar damage is an equally useful predictor of motor disability worsening in the relapsing-remitting phenotype. METHODS: Cerebellar lesion loads and volumes were estimated using baseline magnetic resonance imaging from the CombiRx trial (n = 838). The relationship between cerebellar damage and time to disability worsening (confirmed disability progression [CDP], timed 25-foot walk test [T25FWT] score worsening, nine-hole peg test [9HPT] score worsening) was tested in stagewise and stepwise Cox proportional hazards models, accounting for demographics and supratentorial damage. RESULTS: Shorter time to 9HPT score worsening was associated with higher baseline Expanded Disability Status Scale (EDSS) score (hazard ratio [HR] 1.408, p = 0.0042) and higher volume of supratentorial and cerebellar T2 lesions (HR 1.005 p = 0.0196 and HR 2.211, p = 0.0002, respectively). Shorter time to T25FWT score worsening was associated with higher baseline EDSS (HR 1.232, p = 0.0006). Shorter time to CDP was associated with older age (HR 1.026, p = 0.0010), lower baseline EDSS score (HR 0.428, p < 0.0001) and higher volume of supratentorial T2 lesions (HR 1.024, p < 0.0001). CONCLUSION: Among the explored outcomes, single time-point evaluation of cerebellar damage only allows the prediction of manual dexterity worsening. In clinical studies the selection of imaging biomarkers should be informed by the outcome of interest.","journal":"European Journal of Neurology","year":2021,"id":203870,"datarank":0.3830998294417195,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.11433590905751125,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.11433590905751125,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT00211887"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270886,"name":"Gary Cutter","orcid":"0000-0002-8455-980X","position":1,"is_corresponding":false},{"id":553912,"name":"Sirio Cocozza","orcid":"0000-0002-0300-5160","position":2,"is_corresponding":false},{"id":405189,"name":"Léorah Freeman","orcid":"0000-0002-5696-1797","position":3,"is_corresponding":false},{"id":786168,"name":"John Kangarlu","orcid":null,"position":4,"is_corresponding":false},{"id":785617,"name":"Monica Margoni","orcid":"0000-0002-9232-8964","position":5,"is_corresponding":false},{"id":785618,"name":"Matteo Moro","orcid":"0000-0002-8644-0175","position":6,"is_corresponding":false},{"id":362533,"name":"Stephen Krieger","orcid":null,"position":7,"is_corresponding":false},{"id":785619,"name":"Mohamed Mounir El Mendili","orcid":"0000-0002-4020-0926","position":8,"is_corresponding":false},{"id":785620,"name":"Amgad Droby","orcid":"0000-0002-6182-0059","position":9,"is_corresponding":false},{"id":89329,"name":"Jerry S. Wolinsky","orcid":"0000-0002-8197-2762","position":10,"is_corresponding":false},{"id":89331,"name":"Fred Lublin","orcid":"0000-0001-5722-0475","position":11,"is_corresponding":false},{"id":249019,"name":"Matilde Inglese","orcid":"0000-0002-9610-0297","position":12,"is_corresponding":false},{"id":553913,"name":"Maria Petracca","orcid":"0000-0001-9429-2769","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:51:22.166488Z","pmid":"34695274","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}