{"doi":"10.1111/ejn.70220","title":"Resting‐State Brain Activity in Acute and Chronic Complex Regional Pain Syndrome","abstract":"Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition. Recent brain imaging studies have highlighted the role of cortico-striatal brain circuitry in pain chronification; however, the role of this circuitry in the persistence of CRPS pain has not been studied yet. Here, we investigated whether frequently reported changes in the cortico-striatal brain circuitry in chronic pain extend also to chronic CRPS. CRPS patients were recruited as part of a research study on chronic pain. Quantitative sensory testing and resting-state functional brain activity data were compared between 22 patients with acute CRPS (aCRPS, pain duration, < 12 months) and 20 with chronic CRPS (cCRPS, pain duration, > 12 months). Patients with cCRPS reported decreased sensitivity to pressure pain compared with aCRPS patients. In parallel, resting-state brain activity power within the slow-5 low-frequency band (0.01-0.027 Hz) in the nucleus accumbens-a brain functional signature identified in chronic low-back pain patients-was decreased in cCRPS patients and effectively discriminated acute from chronic CRPS patients, with an area under the curve (AUC) of 0.79. Although cortico-striatal connectivity did not differ between the groups, exploratory whole-brain comparisons revealed stronger connectivities in the aCRPS patients centered mainly on the precuneus/posterior cingulate of the default mode network and the frontal operculum/mid-insula of the ventral attention/salience network. These findings show that cCRPS patients share neuroplasticity in the accumbens with other chronic pain patients and suggest a major shift in functional connectivities affecting networks involved in nociceptive and self-referential processing between aCRPS and cCRPS. Trial Registration: https://drks.de/ - registration number DRKS00016790.","journal":"European Journal of Neuroscience","year":2025,"id":572174,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9642,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1478827,"name":"Mohammad Jammoul","orcid":null,"position":1,"is_corresponding":false},{"id":1478399,"name":"Ann‐Kristin Reinhold","orcid":"0000-0002-0269-462X","position":2,"is_corresponding":false},{"id":1478400,"name":"Juliane Becker","orcid":"0000-0001-5143-4886","position":3,"is_corresponding":false},{"id":1478401,"name":"Michael Alexander Harnik","orcid":"0000-0002-0191-5742","position":4,"is_corresponding":false},{"id":54925,"name":"Madalina E. Tivarus","orcid":"0000-0001-7481-5913","position":5,"is_corresponding":false},{"id":1478402,"name":"György A. Homola","orcid":"0000-0001-9848-2308","position":6,"is_corresponding":false},{"id":1478403,"name":"Magnus Schindehütte","orcid":"0000-0003-3042-3832","position":7,"is_corresponding":false},{"id":1478404,"name":"Grit Hein","orcid":"0000-0001-5696-6486","position":8,"is_corresponding":false},{"id":632135,"name":"Claudia Sommer","orcid":"0000-0002-7064-5002","position":9,"is_corresponding":false},{"id":1361580,"name":"Mirko Pham","orcid":"0000-0003-1295-2685","position":10,"is_corresponding":false},{"id":479157,"name":"Heike L. Rittner","orcid":"0000-0003-4867-0188","position":11,"is_corresponding":false},{"id":938104,"name":"Paul Geha","orcid":"0000-0002-0537-7216","position":12,"is_corresponding":false},{"id":1478826,"name":"Jiechu Chen","orcid":null,"position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":null,"created_at":"2026-07-19T02:57:23.653298Z","pmid":"40799147","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}