{"doi":"10.1111/ejn.15381","title":"Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB <sub>1</sub> receptors expressed in medium spiny neurons","abstract":"Abstract Activation of cannabinoid 1 receptors (CB 1 R) modulates multiple behaviours, including exploration, motor coordination and response to psychostimulants. It is known that CB 1 R expressed by either excitatory or inhibitory neurons mediates different behavioural responses to CB 1 R activation, yet the involvement of CB 1 R expressed by medium spiny neurons (MSNs), the neuronal subpopulation that expresses the highest level of CB 1 R in the CNS, remains unknown. We report a new genetically modified mouse line that expresses functional CB 1 R in MSN on a CB 1 R knockout (KO) background (CB 1 R (MSN) mice). The absence of cannabimimetic responses measured in CB 1 R KO mice was not rescued in CB 1 R (MSN) mice, nor was decreased spontaneous locomotion, impaired instrumental behaviour or reduced amphetamine‐triggered hyperlocomotion measured in CB 1 R KO mice. Significantly, reduced novel environment exploration of an open field and absence of amphetamine sensitization (AS) measured in CB 1 R KO mice were fully rescued in CB 1 R (MSN) mice. Impaired motor coordination in CB 1 R KO mice measured on the Rotarod was partially rescued in CB 1 R (MSN) mice. Thus, CB 1 R expressed by MSN control exploration, motor coordination, and AS. Our study demonstrates a new functional roles for cell specific CB 1 R expression and their causal link in the control of specific behaviors.","journal":"European Journal of Neuroscience","year":2021,"id":197922,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":772460,"name":"Izaskun Elezgarai","orcid":"0000-0003-0880-8058","position":1,"is_corresponding":false},{"id":484669,"name":"Christina M. Gremel","orcid":"0000-0002-8710-0543","position":2,"is_corresponding":false},{"id":773093,"name":"Katie Viray","orcid":null,"position":3,"is_corresponding":false},{"id":512058,"name":"Nigel S. Bamford","orcid":"0000-0003-3375-1022","position":4,"is_corresponding":false},{"id":63050,"name":"Richard D. Palmiter","orcid":"0000-0001-6587-0582","position":5,"is_corresponding":false},{"id":237593,"name":"Pedro Grandes","orcid":"0000-0003-3947-4230","position":6,"is_corresponding":false},{"id":263789,"name":"David M. Lovinger","orcid":"0000-0002-5454-6725","position":7,"is_corresponding":false},{"id":507119,"name":"Nephi Stella","orcid":"0000-0002-4780-8360","position":8,"is_corresponding":false},{"id":772459,"name":"Alipi Bonm","orcid":"0000-0003-0340-2008","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-18T23:50:27.616568Z","pmid":"34216157","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}