{"doi":"10.1111/ejn.14395","title":"Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex","abstract":"AbstractThe rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks mediating this reciprocal dependency are largely unknown. Establishing the developmental timing of network formation will help to understand the emergence of this dependency. We questioned whether the long‐range outputs from HF‐PHR to RSC in Long Evans rats develop during the same time periods as previously reported for the intrinsic HF‐PHR connectivity and the projections from RSC to HF‐PHR. The results of a series of retrograde and anterograde tracing experiments in rats of different postnatal ages show that the postnatal projections from HF‐PHR to RSC display low densities around birth, but develop during the first postnatal week, reaching adult‐like densities around the time of eye‐opening. Developing projections display a topographical organization similar to adult projections. We conclude that the long‐range projections from HF‐PHR to RSC develop in parallel with the intrinsic circuitry of HF‐PHR and the projections of RSC to HF‐PHR.","journal":"European Journal of Neuroscience","year":2019,"id":657077,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1715205,"name":"Jørgen Sugar","orcid":null,"position":1,"is_corresponding":false},{"id":165617,"name":"Menno P. Witter","orcid":"0000-0003-0285-1637","position":2,"is_corresponding":false},{"id":1715204,"name":"Kamilla G. Haugland","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex","abstract":"AbstractThe rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks mediating this reciprocal dependency are largely unknown. Establishing the developmental timing of network formation will help to understand the emergence of this dependency. We questioned whether the long‐range outputs from HF‐PHR to RSC in Long Evans rats develop during the same time periods as previously reported for the intrinsic HF‐PHR connectivity and the projections from RSC to HF‐PHR. The results of a series of retrograde and anterograde tracing experiments in rats of different postnatal ages show that the postnatal projections from HF‐PHR to RSC display low densities around birth, but develop during the first postnatal week, reaching adult‐like densities around the time of eye‐opening. Developing projections display a topographical organization similar to adult projections. We conclude that the long‐range projections from HF‐PHR to RSC develop in parallel with the intrinsic circuitry of HF‐PHR and the projections of RSC to HF‐PHR.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30803071","pmcid":"PMC6767700","openalex_id":"https://openalex.org/W2915904425","authors":[],"funders":[{"funder_name":"The Research Council of Norway","grant_id":"197467","title":"Norwegian Brain Initiative (NORBRAIN):a large-scale infrastructure for 21st century neuroscience"},{"funder_name":"The Research Council of Norway","grant_id":"223262","title":"Centre for Neural Computation (CNC)"},{"funder_name":"European Commission","grant_id":"227769","title":"Failure and Fluid Flow in Porous Quasibrittle Materials"},{"funder_name":"Kavli Foundation","grant_id":"","title":null}],"total_grants":4,"fwci":1.5841,"citation_percentile":0.81719392,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":6},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1111/ejn.14395","host_type":"journal"},{"url":"https://doi.org/10.1111/ejn.14395","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fejn.14395","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/ejn.14395","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ejn.14395","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30803071","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6767700","host_type":"repository"},{"url":"http://hdl.handle.net/11250/2624037","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6767700","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6767700?pdf=render","host_type":"Europe_PMC"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejn.14395","host_type":""},{"url":"http://dx.doi.org/10.1111/ejn.14395","host_type":""},{"url":"https://dx.doi.org/10.1111/ejn.14395","host_type":""}],"fields_of_study":["Memory and Neural Mechanisms","Neuroscience and Neuropharmacology Research","Sleep and Wakefulness Research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Age Factors","Animals","Animals, Newborn","Female","Gyrus Cinguli","Hippocampus","Male","Nerve Net","Neural Pathways","Neuroanatomical Tract-Tracing Techniques","Parahippocampal Gyrus","Rats","Rats, Long-Evans","Staining and Labeling"],"mesh_terms":["Age Factors","Animals","Animals, Newborn","Female","Gyrus Cinguli","Hippocampus","Male","Nerve Net","Neural Pathways","Staining and Labeling","Rats, Long-Evans","Parahippocampal Gyrus","Rats","Neuroanatomical Tract-Tracing Techniques"],"keywords":["Retrosplenial cortex","Hippocampus","Neuroscience","Cortex (anatomy)","Medicine","Psychology","Connectivity","Subiculum","Entorhinal Cortex","Presubiculum","Parasubiculum","Male","Staining and Labeling","Age Factors","Gyrus Cinguli","Rats","Neuroanatomical Tract-Tracing Techniques","Animals, Newborn","Neural Pathways","Animals","Parahippocampal Gyrus","Female","Rats, Long-Evans","Systems Neuroscience","Nerve Net"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T23:36:51.919472Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}