{"doi":"10.1111/ejh.14297","title":"Myeloproliferative Neoplasms and Dementia Risk: A Population‐Based Cohort Study","abstract":"ABSTRACT Objectives To estimate dementia risk for persons diagnosed with Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), which serve as a human chronic inflammation model. Methods We identified 9895 individuals in Denmark newly diagnosed with MPNs from 1995 to 2017; matched them 10:1 by age and sex with a general population cohort of 95 770 individuals; and followed them until dementia identification, death, emigration, or December 31, 2018. We applied a Cox proportional‐hazards regression model to estimate the cause‐specific hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia. We included control diseases, like chronic lymphocytic leukemia (CLL), which is not characterized by chronic inflammation. Results Patients with MPNs showed a 1.15‐fold (95% CI: 1.04–1.27) increased incidence of dementia compared with members of the general population. Associations were stronger for men with MPNs (HR: 1.40, 95% CI: 1.19–1.63) than for women (HR: 1.02, 95% CI: 0.89–1.15). Patients with CLL showed a decreased dementia incidence (HR: 0.81, 95% CI: 0.72–0.90). The findings for CLL could be explained by depletion‐of‐susceptibles bias, suggesting that the findings for MPNs were underestimated by a similar bias. Conclusions The findings support MPNs as risk factors for dementia and the role of chronic inflammation in dementia development.","journal":"European Journal Of Haematology","year":2024,"id":474061,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6273,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355539,"name":"Katalin Veres","orcid":"0000-0001-8549-8781","position":1,"is_corresponding":false},{"id":653809,"name":"Hans Carl Hasselbalch","orcid":"0000-0003-3936-8032","position":2,"is_corresponding":false},{"id":715617,"name":"Henrik Frederiksen","orcid":"0000-0001-8905-0220","position":3,"is_corresponding":false},{"id":787814,"name":"Lene Sofie Granfeldt Østgård","orcid":"0000-0002-3886-1311","position":4,"is_corresponding":false},{"id":355538,"name":"Erzsébet Horváth–Puhó","orcid":"0000-0002-3594-2212","position":5,"is_corresponding":false},{"id":355540,"name":"Victor W. Henderson","orcid":"0000-0003-1198-9240","position":6,"is_corresponding":false},{"id":236234,"name":"Henrik Toft Sørensen","orcid":"0000-0003-4299-7040","position":7,"is_corresponding":false},{"id":1310289,"name":"Yuelian Sun","orcid":"0000-0002-6905-0503","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:06:09.108857Z","pmid":"39279726","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}