{"doi":"10.1111/ejh.13622","title":"Cytokine gene polymorphisms are associated with response to blinatumomab in B‐cell acute lymphoblastic leukemia","abstract":"Blinatumomab is a bispecific T cell-engaging antibody approved for treatment of relapsed/refractory (r/r) ALL, with 40%-50% complete response (CR)/CR with incomplete count recovery (CRi). Cytokine release syndrome (CRS) as a major adverse effect after blinatumomab therapy. Here, we evaluated the possible association between single-nucleotide polymorphisms (SNPs) in cytokine genes, disease response, and CRS in r/r ALL patients who received blinatumomab between 2012 and 2017 at our center (n = 66), using patients' archived DNA samples. With a median duration of 9.5 months (range: 1-37), 37 patients (56.1%) achieved CR/CRi, 54 (81.8%) experienced CRS (G1: n = 35, G2: n = 14, G3: n = 5), and 9 (13.6%) developed neurotoxicity. By multivariable analysis, after adjusting for high disease burden, one SNP on IL2 (rs2069762), odds ratio (OR) = 0.074 (95% CI: NE-0.43, P = .01) and one SNP on IL17A (rs4711998), OR = 0.28 (95% CI: 0.078-0.92, P = .034) were independently associated with CR/CRi. None of the analyzed SNPs were associated with CRS. To our knowledge, this is the first study demonstrating a possible association between treatment response to blinatumomab and SNPs. Our hypothesis-generated data suggest a potential role for IL-17 and IL-2 in blinatumomab response and justify a larger confirmatory study, which may lead to personalized blinatumomab immunotherapy for B-ALL.","journal":"European Journal Of Haematology","year":2021,"id":206657,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9619,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":233349,"name":"Ibrahim Aldoss","orcid":"0000-0001-9564-4498","position":1,"is_corresponding":false},{"id":318404,"name":"Dongyun Yang","orcid":"0000-0003-0736-4977","position":2,"is_corresponding":false},{"id":319462,"name":"Sally Mokhtari","orcid":null,"position":3,"is_corresponding":false},{"id":783557,"name":"Ketevan Gendzekhadze","orcid":"0000-0001-5865-0792","position":4,"is_corresponding":false},{"id":387641,"name":"Samer K. Khaled","orcid":"0000-0003-3554-4625","position":5,"is_corresponding":false},{"id":791606,"name":"Margaret O’Donnell","orcid":null,"position":6,"is_corresponding":false},{"id":436064,"name":"Joycelynne Palmer","orcid":"0000-0001-6480-7557","position":7,"is_corresponding":false},{"id":423661,"name":"Joo Y. Song","orcid":"0000-0003-3497-2513","position":8,"is_corresponding":false},{"id":108574,"name":"Guido Marcucci","orcid":"0000-0002-3983-5908","position":9,"is_corresponding":false},{"id":89270,"name":"Anthony S. Stein","orcid":"0000-0002-1786-1398","position":10,"is_corresponding":false},{"id":249979,"name":"Stephen J. Forman","orcid":"0000-0002-2803-4152","position":11,"is_corresponding":false},{"id":387643,"name":"Vinod Pullarkat","orcid":"0000-0001-9129-3424","position":12,"is_corresponding":false},{"id":791073,"name":"Wei Chen","orcid":"0009-0000-0883-2547","position":13,"is_corresponding":false},{"id":108571,"name":"Xiwei Wu","orcid":"0000-0002-7071-1671","position":14,"is_corresponding":false},{"id":284156,"name":"Ryotaro Nakamura","orcid":"0000-0002-9082-0680","position":15,"is_corresponding":false},{"id":791072,"name":"Nikeshan Jeyakumar","orcid":"0000-0001-9979-4434","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T23:51:41.571653Z","pmid":"33721333","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}