{"doi":"10.1111/edt.12093","title":"Expression of Small Integrin‐Binding LIgand N‐linked Glycoproteins (<scp>SIBLING</scp>s) in the reparative dentin of rat molars","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>To analyze the expression and distribution of Small Integrin‐Binding LIgand N‐linked Glycoproteins (<jats:styled-content style=\"fixed-case\">SIBLING</jats:styled-content>s) in reparative dentin (RepD).</jats:p></jats:sec><jats:sec><jats:title>Methodology</jats:title><jats:p>Cavities on the mesial surfaces of rat molars were prepared to expose the pulp, and a calcium hydroxide agent was applied to cap the exposed pulp. The molars with pulp capping were extracted at postoperative 1, 2, and 4 weeks. The immunolocalization of four <jats:styled-content style=\"fixed-case\">SIBLING</jats:styled-content>s, dentin matrix protein 1 (<jats:styled-content style=\"fixed-case\">DMP</jats:styled-content>1), dentin sialoprotein (<jats:styled-content style=\"fixed-case\">DSP</jats:styled-content>), bone sialoprotein (<jats:styled-content style=\"fixed-case\">BSP</jats:styled-content>), and osteopontin (<jats:styled-content style=\"fixed-case\">OPN</jats:styled-content>) in RepD, was analyzed in comparison with reactionary dentin (ReaD) and primary dentin (<jats:styled-content style=\"fixed-case\">PD</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At two weeks after operation, the region of the exposed pulp formed a layer of reparative dentin bridge sealing the communication between the cavity and pulp chamber. Dentinal tubules in RepD were more irregular in shape and fewer in number than <jats:styled-content style=\"fixed-case\">PD</jats:styled-content>. At postoperative 2 and 4 weeks, RepD had lower levels of <jats:styled-content style=\"fixed-case\">DMP</jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">DSP</jats:styled-content> than <jats:styled-content style=\"fixed-case\">PD</jats:styled-content>. <jats:styled-content style=\"fixed-case\">BSP</jats:styled-content> and <jats:styled-content style=\"fixed-case\">OPN</jats:styled-content> were present in RepD, but not in <jats:styled-content style=\"fixed-case\">PD</jats:styled-content>. RepD showed certain similarities to ReaD in the expression of <jats:styled-content style=\"fixed-case\">SIBLING</jats:styled-content>s.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The reduced levels of <jats:styled-content style=\"fixed-case\">DMP</jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">DSP</jats:styled-content> may be associated with the decreased number of dentinal tubules in RepD. The expression of <jats:styled-content style=\"fixed-case\">BSP</jats:styled-content> and <jats:styled-content style=\"fixed-case\">OPN</jats:styled-content> in RepD indicates that the odontoblast‐like cells were attempting to produce a hard tissue at a very rapid pace. These findings suggest that in response to the surgical injury, the newly differentiated odontoblast‐like cells altered their synthesis of the dentinogenesis‐related proteins and produced a hard tissue that is an intermediate between dentin and bone.</jats:p></jats:sec>","journal":"Dental Traumatology","year":2014,"id":681794,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1781299,"name":"Su Ma","orcid":null,"position":1,"is_corresponding":false},{"id":1303495,"name":"Changcheng Li","orcid":"0000-0003-4738-8092","position":2,"is_corresponding":false},{"id":1781300,"name":"Peihong Liu","orcid":null,"position":3,"is_corresponding":false},{"id":1025503,"name":"Haixia Wang","orcid":"0000-0002-5782-8242","position":4,"is_corresponding":false},{"id":640877,"name":"Li Chen","orcid":"0000-0001-5561-7612","position":5,"is_corresponding":false},{"id":1286077,"name":"Chunlin Qin","orcid":"0000-0002-2906-9074","position":6,"is_corresponding":false},{"id":1688541,"name":"Xiaohua Xie","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression of Small Integrin‐Binding LIgand N‐linked Glycoproteins (<scp>SIBLING</scp>s) in the reparative dentin of rat molars","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>To analyze the expression and distribution of Small Integrin‐Binding LIgand N‐linked Glycoproteins (<jats:styled-content style=\"fixed-case\">SIBLING</jats:styled-content>s) in reparative dentin (RepD).</jats:p></jats:sec><jats:sec><jats:title>Methodology</jats:title><jats:p>Cavities on the mesial surfaces of rat molars were prepared to expose the pulp, and a calcium hydroxide agent was applied to cap the exposed pulp. The molars with pulp capping were extracted at postoperative 1, 2, and 4 weeks. The immunolocalization of four <jats:styled-content style=\"fixed-case\">SIBLING</jats:styled-content>s, dentin matrix protein 1 (<jats:styled-content style=\"fixed-case\">DMP</jats:styled-content>1), dentin sialoprotein (<jats:styled-content style=\"fixed-case\">DSP</jats:styled-content>), bone sialoprotein (<jats:styled-content style=\"fixed-case\">BSP</jats:styled-content>), and osteopontin (<jats:styled-content style=\"fixed-case\">OPN</jats:styled-content>) in RepD, was analyzed in comparison with reactionary dentin (ReaD) and primary dentin (<jats:styled-content style=\"fixed-case\">PD</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At two weeks after operation, the region of the exposed pulp formed a layer of reparative dentin bridge sealing the communication between the cavity and pulp chamber. Dentinal tubules in RepD were more irregular in shape and fewer in number than <jats:styled-content style=\"fixed-case\">PD</jats:styled-content>. At postoperative 2 and 4 weeks, RepD had lower levels of <jats:styled-content style=\"fixed-case\">DMP</jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">DSP</jats:styled-content> than <jats:styled-content style=\"fixed-case\">PD</jats:styled-content>. <jats:styled-content style=\"fixed-case\">BSP</jats:styled-content> and <jats:styled-content style=\"fixed-case\">OPN</jats:styled-content> were present in RepD, but not in <jats:styled-content style=\"fixed-case\">PD</jats:styled-content>. RepD showed certain similarities to ReaD in the expression of <jats:styled-content style=\"fixed-case\">SIBLING</jats:styled-content>s.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The reduced levels of <jats:styled-content style=\"fixed-case\">DMP</jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">DSP</jats:styled-content> may be associated with the decreased number of dentinal tubules in RepD. The expression of <jats:styled-content style=\"fixed-case\">BSP</jats:styled-content> and <jats:styled-content style=\"fixed-case\">OPN</jats:styled-content> in RepD indicates that the odontoblast‐like cells were attempting to produce a hard tissue at a very rapid pace. These findings suggest that in response to the surgical injury, the newly differentiated odontoblast‐like cells altered their synthesis of the dentinogenesis‐related proteins and produced a hard tissue that is an intermediate between dentin and bone.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24502800","pmcid":null,"openalex_id":"https://openalex.org/W2035630951","authors":[],"funders":[{"funder_name":"Natural Science Foundation of China","grant_id":"81171744","title":null}],"total_grants":1,"fwci":1.6132,"citation_percentile":0.82042292,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2020,"count":24},{"year":2022,"count":1},{"year":2023,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fedt.12093","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/edt.12093","host_type":"publisher"},{"url":"https://doi.org/10.1111/edt.12093","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24502800","host_type":"repository"}],"fields_of_study":["Bone and Dental Protein Studies","Endodontics and Root Canal Treatments","Dental Erosion and Treatment","Animals","Dentin","Glycoproteins","Immunohistochemistry","Integrins","Ligands","Molar","Rats","Rats, Wistar"],"mesh_terms":["Animals","Dentin","Glycoproteins","Immunohistochemistry","Ligands","Molar","Integrins","Rats, Wistar","Rats"],"keywords":["Molar","Glycoprotein","Integrin","Dentin","Chemistry","Cell biology","Ligand (biochemistry)","Molecular biology","Dentistry","Biology","Medicine","Biochemistry","Cell","Receptor","Bone sialoprotein","osteopontin","Reparative Dentin","Dentin Sialoprotein","Dentin Matrix Protein 1"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T18:40:40.852316Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}