{"doi":"10.1111/dom.14695","title":"A low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth","abstract":"AIM: To examine the determinants and metabolic impact of the reduction in fasting and postload insulin levels after a low n-6 to n-3 polyunsaturated fatty acid (PUFA) ratio diet in obese youth. MATERIALS AND METHODS: Insulin secretion and clearance were assessed by measuring and modelling plasma insulin and C-peptide in 17 obese youth who underwent a nine-point, 180-minute oral glucose tolerance test (OGTT) before and after a 12-week, eucaloric low n-6:n-3 polyunsaturated fatty acid (PUFA) ratio diet. Hepatic fat content was assessed by repeated abdominal magnetic resonance imaging. RESULTS: Insulin clearance at fasting and during the OGTT was significantly increased after the diet, while body weight, glucose levels, absolute and glucose-dependent insulin secretion, and model-derived variables of β-cell function were not affected. Dietary-induced changes in insulin clearance positively correlated with changes in whole-body insulin sensitivity and β-cell glucose sensitivity, but not with changes in hepatic fat. Subjects with greater increases in insulin clearance showed a worse metabolic profile at enrolment, characterized by impaired insulin clearance, β-cell glucose sensitivity, and glucose tolerance, and benefitted the most from the diet, achieving greater improvements in glucose-stimulated hyperinsulinaemia, insulin resistance, and β-cell function. CONCLUSIONS: We showed that a 12-week low n-6:n-3 PUFA ratio diet improves hyperinsulinaemia by increasing fasting and postload insulin clearance in obese youth, independently of weight loss, glucose concentrations, and insulin secretion.","journal":"Diabetes Obesity and Metabolism","year":2022,"id":271557,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":425771,"name":"Alfonso Galderisi","orcid":"0000-0001-8885-3056","position":1,"is_corresponding":false},{"id":371626,"name":"Michelle Van Name","orcid":"0000-0001-7672-4230","position":2,"is_corresponding":false},{"id":262979,"name":"Sonia Caprio","orcid":"0000-0002-7523-5053","position":3,"is_corresponding":false},{"id":936951,"name":"Stephanie Samuels","orcid":"0000-0002-0873-9841","position":4,"is_corresponding":false},{"id":758299,"name":"Zhongyao Li","orcid":"0000-0002-3295-7718","position":5,"is_corresponding":false},{"id":293070,"name":"Brittany Galuppo","orcid":"0000-0003-4389-5118","position":6,"is_corresponding":false},{"id":524896,"name":"Mary Savoye","orcid":null,"position":7,"is_corresponding":false},{"id":285389,"name":"Andrea Mari","orcid":"0000-0002-1436-5591","position":8,"is_corresponding":false},{"id":302637,"name":"Ariel E. Feldstein","orcid":"0000-0001-7202-3840","position":9,"is_corresponding":false},{"id":263015,"name":"Nicola Santoro","orcid":"0000-0001-6437-4173","position":10,"is_corresponding":false},{"id":425772,"name":"Domenico Tricò","orcid":"0000-0002-7633-1346","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:27:39.717534Z","pmid":"35297549","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}