{"doi":"10.1111/dom.14182","title":"Short‐term intestinal lipase inhibition in normal‐weight individuals does not affect postprandial peptide YY <sub> <scp>3</scp> ‐36 </sub> and glucagon‐like peptide‐1 levels, hunger or satiety","abstract":"Abstract Fat malabsorption associated with Roux‐en‐Y gastric bypass (RYGB) may contribute to elevated postprandial glucagon‐like peptide‐1 (GLP‐1) and peptide YY (PYY) after the procedure, leading to sustained weight loss and appetite reduction. This study investigated whether fat malabsorption via orlistat increases GLP‐1 and PYY and if these increases would be proportional to changes in hunger and satiety. Five healthy participants received standardized meals with 120 mg orlistat or placebo in a randomized, double‐blinded, crossover design for 3 days. On the final day, glucose, insulin, GLP‐1, PYY 3‐36 and visual analogue scores for hunger and satiety were measured over a 14‐hour period that included three meals. Fasting, 14‐hour area under the curve (AUC) and meal‐related AUC for glucose and insulin were similar, although postprandial increases in peak insulin and glucose were greater with orlistat. PYY 3‐36 , GLP‐1, hunger and satiety were not different. In conclusion, short‐term orlistat administration does not enhance postprandial GLP‐1 or PYY 3‐36 or affect hunger or satiety in normal‐weight individuals. Furthermore, fat malabsorption from RYGB is unlikely to mediate subsequent postprandial increases in GLP‐1 and PYY.","journal":"Diabetes Obesity and Metabolism","year":2020,"id":111893,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":530378,"name":"Irina Kolobova","orcid":"0000-0002-7373-1301","position":1,"is_corresponding":false},{"id":530379,"name":"Bruce M. Wolfe","orcid":"0000-0002-3373-1198","position":2,"is_corresponding":false},{"id":505247,"name":"Jonathan Q. Purnell","orcid":"0000-0001-5505-6333","position":3,"is_corresponding":false},{"id":530377,"name":"Nga Nguyen","orcid":"0000-0002-0176-4577","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-18T23:13:09.353152Z","pmid":"32869451","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}