{"doi":"10.1111/dgd.12197","title":"Engrailed and tectum development","abstract":"<jats:p>The optic tectum is a visual center of nonmammalian vertebrates derived from the mesencephalon. In this review, function of Engrailed (En) in tectum development is reviewed. En plays crucial roles at three steps of tectum development. First, Engrailed is expressed in the mesencephalon and the metencephalon and essential for the regionalization of the mesencephalon. En is expressed in a gradient of caudal‐to‐rostral in the tectum primordial, and regulates the rostrocaudal polarity of the tectum. In the advanced stage of tectum development, En is expressed in a lamina‐specific manner and it is suggested that En regulates cell migration in the tectal laminar formation.</jats:p>","journal":"Development, Growth &amp; Differentiation","year":2015,"id":637247,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1654485,"name":"Harukazu Nakamura","orcid":null,"position":1,"is_corresponding":false},{"id":1654483,"name":"Minoru Omi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Engrailed and tectum development","abstract":"<jats:p>The optic tectum is a visual center of nonmammalian vertebrates derived from the mesencephalon. 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In the advanced stage of tectum development, En is expressed in a lamina‐specific manner and it is suggested that En regulates cell migration in the tectal laminar formation.</jats:p>","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25716935","pmcid":null,"openalex_id":"https://openalex.org/W2047427533","authors":[],"funders":[{"funder_name":"Ministry of Education, Culture, Sports, Science, and Technology","grant_id":"17023003","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"22570199","title":null},{"funder_name":"Tohoku Neuroscience Global COE","grant_id":"","title":null}],"total_grants":3,"fwci":0.1378,"citation_percentile":0.53409519,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2025,"count":2}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12197","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12197","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fdgd.12197","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/dgd.12197","host_type":"publisher"},{"url":"https://doi.org/10.1111/dgd.12197","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25716935","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Axon Guidance and Neuronal Signaling","Corneal Surgery and Treatments","Animals","Cell Movement","Embryo, Nonmammalian","Homeodomain Proteins","Superior Colliculi"],"mesh_terms":["Animals","Cell Movement","Embryo, Nonmammalian","Superior Colliculi","Homeodomain Proteins"],"keywords":["Tectum","Midbrain","engrailed","Neuroscience","Biology","Laminar organization","Tegmentum","Optic tectum","Superior Colliculi","Anatomy","Retina","Visual system","Central nervous system","Homeobox","Regionalization","Laminar Formation","Rostrocaudal Polarity"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:37:50.023802Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}