{"doi":"10.1111/cup.14242","title":"Immune cell subsets in interface cutaneous immune‐related adverse events associated with <scp>anti‐PD</scp>‐1 therapy resemble acute graft versus host disease more than lichen planus","abstract":"BACKGROUND: Checkpoint immunotherapy is frequently associated with cutaneous immune-related adverse events (cirAEs), and among those, the most common subtype shows interface reaction patterns that have been likened to lichen planus (LP); however, cutaneous acute graft versus host disease (aGVHD) may be a closer histopathologic comparator. We used quantitative pathology to compare the immunologic composition of anti-PD-1-associated interface reactions to LP and aGVHD to assess for similarities and differences between these cutaneous eruptions. METHODS: Immunohistochemistry for CD4, CD8, CD68, PD-1, and PD-L1 was performed on formalin-fixed paraffin-embedded tissue from patients with anti-PD-1 interface cirAEs (n = 4), LP (n = 9), or aGVHD (n = 5). Densities of immune cell subsets expressing each marker were quantified using the HALO image analysis immune cell module. Plasma cell and eosinophil density were quantified on routine H&E slides. RESULTS: Specimens from patients with anti-PD-1 interface cirAEs showed equivalent total cell densities and immune cell composition to those with aGVHD. Patients with LP showed higher total immune cell infiltration, higher absolute T-cell densities, increased CD8 proportion, and reduced histiocytic component. The cases with the highest plasma cell counts were all anti-PD-1 interface cirAEs and aGVHD. CONCLUSION: The composition of immune cell subsets in anti-PD-1 interface cirAEs more closely resembles the immune response seen in aGVHD than LP within our cohort. This warrants a closer look via advanced analytics and may have implications for shared pathogenesis and potential treatment options.","journal":"Journal of Cutaneous Pathology","year":2022,"id":284794,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":724392,"name":"Genevieve J. Kaunitz","orcid":"0000-0001-9619-0109","position":1,"is_corresponding":false},{"id":300425,"name":"Julie E. Stein","orcid":null,"position":2,"is_corresponding":false},{"id":623379,"name":"Inbal Sander","orcid":"0000-0001-6045-3165","position":3,"is_corresponding":false},{"id":616305,"name":"Travis J. Hollmann","orcid":"0000-0003-0258-3003","position":4,"is_corresponding":false},{"id":254620,"name":"Tricia R. Cottrell","orcid":"0000-0003-2952-1830","position":5,"is_corresponding":false},{"id":59435,"name":"Janis M. Taube","orcid":"0000-0002-8273-4395","position":6,"is_corresponding":false},{"id":623383,"name":"Joel Sunshine","orcid":"0000-0001-9987-6712","position":7,"is_corresponding":false},{"id":963003,"name":"Guillermo E. Almodovar Cruz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T00:29:36.828109Z","pmid":"35445765","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}