{"doi":"10.1111/ctr.70071","title":"Increased Mortality in Kidney Transplant Recipients During the Delta/Omicron Era of the COVID‐19 Pandemic Despite Widespread Vaccination","abstract":"<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>The incidence of mortality late in the pandemic, particularly after widespread vaccine availability, is not well understood. Herein, we elucidate the effect of this impact of the COVID pandemic as well as risk factors for mortality during it.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The primary end point was death with a functioning graft with secondary endpoints of mortality rates in subgroups and at different time intervals during the pandemic.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Despite widespread vaccination, mortality rates for kidney transplant (KTx) recipients almost doubled during the COVID‐19 era (6.40 deaths per 100 person years vs. 3.54 pre‐COVID). Mortality increased in all racial/ethnic groups but increased more in Native Americans, Hispanics, and African Americans compared to non‐Hispanic Caucasians. The highest mortality rate occurred during the Delta and Omicron time frames. In contrast to the general population, mortality was more evenly spread across age groups in KTx recipients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Mortality rates during the COVID‐19 era were extremely high, more than doubling in some racial/ethnic groups. We conclude that the KTx population was a particularly vulnerable group during the COVID‐19 era and suggests the need for further research into the management of variants in the future.</jats:p></jats:sec>","journal":"Clinical Transplantation","year":2025,"id":626969,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1622199,"name":"Sumi Nair","orcid":null,"position":1,"is_corresponding":false},{"id":1021377,"name":"Hani M. 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Smith","orcid":"0000-0001-9318-2437","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Increased Mortality in Kidney Transplant Recipients During the Delta/Omicron Era of the COVID‐19 Pandemic Despite Widespread Vaccination","abstract":"<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>The incidence of mortality late in the pandemic, particularly after widespread vaccine availability, is not well understood. Herein, we elucidate the effect of this impact of the COVID pandemic as well as risk factors for mortality during it.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The primary end point was death with a functioning graft with secondary endpoints of mortality rates in subgroups and at different time intervals during the pandemic.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Despite widespread vaccination, mortality rates for kidney transplant (KTx) recipients almost doubled during the COVID‐19 era (6.40 deaths per 100 person years vs. 3.54 pre‐COVID). Mortality increased in all racial/ethnic groups but increased more in Native Americans, Hispanics, and African Americans compared to non‐Hispanic Caucasians. The highest mortality rate occurred during the Delta and Omicron time frames. In contrast to the general population, mortality was more evenly spread across age groups in KTx recipients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Mortality rates during the COVID‐19 era were extremely high, more than doubling in some racial/ethnic groups. We conclude that the KTx population was a particularly vulnerable group during the COVID‐19 era and suggests the need for further research into the management of variants in the future.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39777936","pmcid":null,"openalex_id":"https://openalex.org/W4406145012","authors":[],"funders":[],"total_grants":0,"fwci":4.087,"citation_percentile":0.93071264,"influential_citations":0,"citation_trend":[{"year":2025,"count":5}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/ctr.70071","host_type":"publisher"},{"url":"https://doi.org/10.1111/ctr.70071","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39777936","host_type":"repository"}],"fields_of_study":["SARS-CoV-2 and COVID-19 Research","Renal Transplantation Outcomes and Treatments","COVID-19 Clinical Research Studies","Humans","Kidney Transplantation","COVID-19","Male","Female","Middle Aged","Adult","SARS-CoV-2","Vaccination","Aged","Transplant Recipients","Risk Factors","COVID-19 Vaccines","Pandemics","Kidney Failure, Chronic","United States","Survival Rate"],"mesh_terms":["COVID-19","SARS-CoV-2","COVID-19 Vaccines","Adult","Aged","Female","Humans","Kidney Failure, Chronic","Male","Middle Aged","Risk Factors","United States","Vaccination","Survival Rate","Kidney Transplantation","Pandemics","Transplant Recipients"],"keywords":["Medicine","Pandemic","Demography","Vaccination","Mortality rate","Incidence (geometry)","Population","Ethnic group","Coronavirus disease 2019 (COVID-19)","Internal medicine","Immunology","Environmental health","Disease","Infectious disease (medical specialty)","Statistics","Ethnicity/race","Infection And Infectious Agents"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T15:49:38.549594Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}