{"doi":"10.1111/ctr.15295","title":"A2/A2B to B kidney transplantation outcomes: A single center 7‐year experience","abstract":"INTRODUCTION: Data on long-term outcomes following A2/A2B to B kidney transplants since the 2014 kidney allocation system (KAS) changes are few. The primary aim of this study is to report our 7-year experience with A2/A2B to B kidney transplants and to compare post-transplant outcomes of A2/A2B to a concurrent group of B to B kidney transplants. Additionally, the study evaluates the impact of pre-transplant anti-A1 titers on survival outcomes in A2/A2B transplants. METHODS: This retrospective, single-center analysis included all adults who received A2/A2B to B deceased donor kidney transplants from December 2014 to June 2021 compared to B to B recipients. The effects of pre-transplant IgM/IgG titers, stratified as ≤1:8 and ≥1:16, on death-censored, rejection-free, and overall graft survival were tested. RESULTS: Fifty-three A2/A2B and 114 B to B adults were included with a median follow-up time of 32 months. Overall graft survival, patient survival, and rejection-free graft survival did not differ between the two groups. There were no differences between the groups' overall kidney function values (p > .80) or their temporal trajectories (time by group interaction p > .11). Unadjusted death-censored graft survival was lower in A2/A2B to B compared to B recipients (p = .03), but the effect was not significant (p = .195) after adjusting for any readmissions (p = .96), rejection episodes (p < .001) or BK infection (p = .76). We did not detect an effect of pre-transplant titer group on death-censored (p = .59), rejection-free (p = .61), or overall graft survival (p = .26) CONCLUSIONS: A2/A2B to B kidney transplants have comparable overall patient and graft survival, rejection-free graft survival, and longitudinal renal function compared to B to B transplants at our center. Allograft survival outcomes were not significantly different between patients with low and high pre-transplant anti-A1 IgM/IgG titers.","journal":"Clinical Transplantation","year":2024,"id":478592,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9465,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1156030,"name":"Saed Shawar","orcid":"0000-0002-4602-5700","position":1,"is_corresponding":false},{"id":530325,"name":"Mohammad Kazem Fallahzadeh","orcid":"0000-0002-7348-3504","position":2,"is_corresponding":false},{"id":486539,"name":"Rachel C. Forbes","orcid":"0000-0001-6827-791X","position":3,"is_corresponding":false},{"id":1156033,"name":"Heidi Schaefer","orcid":"0000-0001-5058-2684","position":4,"is_corresponding":false},{"id":781244,"name":"Irene D. Feurer","orcid":"0000-0001-5444-5695","position":5,"is_corresponding":false},{"id":781245,"name":"Scott A. Rega","orcid":"0000-0003-2205-2314","position":6,"is_corresponding":false},{"id":669647,"name":"Jefferson L. Triozzi","orcid":"0000-0002-3607-6838","position":7,"is_corresponding":false},{"id":625149,"name":"David R. Shaffer","orcid":"0000-0002-3040-7499","position":8,"is_corresponding":false},{"id":1317380,"name":"Alissar El Chediak","orcid":"0000-0003-3694-8808","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:06:46.330532Z","pmid":"38545909","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}