{"doi":"10.1111/ctr.15097","title":"Cystic fibrosis survival outcomes following second lung transplant: The north American experience","abstract":"INTRODUCTION: Re-transplant is an option for those who develop end-stage lung disease due to rejection; however, little data exist following re-transplantation in cystic fibrosis (CF). METHODS: Data from the Canadian CF Registry and US CF Foundation Patient Registry supplemented with data from United Network for Organ Sharing were used. Individuals who underwent a 2nd lung transplant between 2005 and 2019 were included. The Kaplan-Meier method was used to estimate the probability of survival post-second transplant at 1, 3, and 5-years. RESULTS: Of those people who were waitlisted for a second transplant (N = 818), a total of 254 (31%) died waiting, 395 (48%) were transplanted and 169 (21%) people were alive on the waitlist. Median survival time after 2nd lung transplant was 3.3 years (95% CI: 2.8-4.1). The 1-, 3- and 5-year survival rates were 77.4% (95% CI: 73.1-82%), 52% (95% CI: 46.7-58%) and 39.4% (95% CI: 34.1-45.6%). CONCLUSIONS: Survival following second lung transplant in CF patients is lower than estimates following the first transplant. Over half of subjects who are potentially eligible for a second transplant die without receiving a second organ. This warrants further investigation.","journal":"Clinical Transplantation","year":2023,"id":361053,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6884,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":380586,"name":"Kathleen J. Ramos","orcid":"0000-0002-2309-368X","position":1,"is_corresponding":false},{"id":487095,"name":"Jenna Sykes","orcid":"0000-0002-3282-9361","position":2,"is_corresponding":false},{"id":487096,"name":"Xiayi Ma","orcid":"0000-0003-3504-7637","position":3,"is_corresponding":false},{"id":487097,"name":"Sanja Stanojevic","orcid":"0000-0001-7931-8051","position":4,"is_corresponding":false},{"id":486168,"name":"Bradley S. Quon","orcid":"0000-0003-1785-3870","position":5,"is_corresponding":false},{"id":333032,"name":"Bruce C. Marshall","orcid":null,"position":6,"is_corresponding":false},{"id":61094,"name":"Elizabeth A. Cromwell","orcid":"0000-0002-5106-0607","position":7,"is_corresponding":false},{"id":487753,"name":"Joshua S. Ostrenga","orcid":null,"position":8,"is_corresponding":false},{"id":380584,"name":"Albert Faro","orcid":"0000-0001-8408-6371","position":9,"is_corresponding":false},{"id":487099,"name":"Alexander Elbert","orcid":"0000-0002-2134-5118","position":10,"is_corresponding":false},{"id":603252,"name":"Jonathan Todd","orcid":"0000-0001-6396-2379","position":11,"is_corresponding":false},{"id":487100,"name":"Cecilia Chaparro","orcid":"0000-0003-1674-375X","position":12,"is_corresponding":false},{"id":460724,"name":"Christopher H. Goss","orcid":"0000-0001-8602-0309","position":13,"is_corresponding":false},{"id":487094,"name":"Anne L. Stephenson","orcid":"0000-0002-4529-5653","position":14,"is_corresponding":false},{"id":1113823,"name":"Moayad Khalid Alshehri","orcid":null,"position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T01:14:10.680991Z","pmid":"37563332","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}