{"doi":"10.1111/ctr.14802","title":"Role of time from transplantation to biopsy in histologic ABMR: A single center report","abstract":"BACKGROUND: Allograft biopsies with lesions of Antibody-Mediated Rejection (ABMR) with Microvascular Inflammation (MVI) have shown heterogeneous etiologies and outcomes. METHODS: To examine factors associated with outcomes in biopsies that meet histologic ABMR criteria, we retrospectively evaluated for-cause biopsies at our center between 2011 and 2017. We included biopsies that met the diagnosis of ABMR by histology, along with simultaneous evaluation for anti-Human Leukocyte Antigen (HLA) donor-specific antibodies (DSA). We evaluated death-censored graft loss (DCGL) and used a principal component analysis (PCA) approach to identify key predictors of outcomes. RESULTS: Out of the histologic ABMR cohort (n = 118), 70 were DSA-positive ABMR, while 48 had no DSA. DSA(+)ABMR were younger and more often female recipients. DSA(+)ABMR occurred significantly later post-transplant than DSA(-)ABMR suggesting time-dependence. DSA(+)ABMR had higher inflammatory scores (i,t), chronicity scores (ci, ct) and tended to have higher MVI scores. Immunodominance of DQ-DSA in DSA(+)ABMR was associated with higher i+t scores. Clinical/histologic factors significantly associated with DCGL after biopsy were inputted into the PCA. Principal component-1 (PC-1), which contributed 34.8% of the variance, significantly correlated with time from transplantation to biopsy, ci/ct scores and DCGL. In the PCA analyses, i, t scores, DQ-DSA, and creatinine at biopsy retained significant correlations with GL-associated PCs. CONCLUSIONS: Time from transplantation to biopsy plays a major role in the prognosis of biopsies with histologic ABMR and MVI, likely due to ongoing chronic allograft injury over time.","journal":"Clinical Transplantation","year":2022,"id":279351,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9345,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":296187,"name":"Caroline Liu","orcid":"0000-0002-6684-026X","position":1,"is_corresponding":false},{"id":340053,"name":"Kinsuk Chauhan","orcid":"0000-0002-1198-3562","position":2,"is_corresponding":false},{"id":952922,"name":"Lisa Andersen","orcid":null,"position":3,"is_corresponding":false},{"id":952466,"name":"Cynthia Harris","orcid":"0000-0002-2530-5519","position":4,"is_corresponding":false},{"id":241218,"name":"Steven G. 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Formica","orcid":"0000-0001-6452-3976","position":11,"is_corresponding":false},{"id":714385,"name":"Anand Reghuvaran","orcid":"0000-0002-5656-0205","position":12,"is_corresponding":false},{"id":469752,"name":"Khadija Banu","orcid":"0000-0001-6680-2688","position":13,"is_corresponding":false},{"id":461186,"name":"Sander Florman","orcid":"0000-0002-1635-9136","position":14,"is_corresponding":false},{"id":247113,"name":"Enver Akalin","orcid":"0000-0003-1341-5144","position":15,"is_corresponding":false},{"id":952468,"name":"Ron Shapiro","orcid":"0000-0003-1213-2142","position":16,"is_corresponding":false},{"id":439527,"name":"Fadi Salem","orcid":"0000-0002-2603-2778","position":17,"is_corresponding":false},{"id":385517,"name":"Madhav C. 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