{"doi":"10.1111/cpr.13367","title":"Eukaryotic translation initiation factor <scp>eIF4G2</scp> opens novel paths for protein synthesis in development, apoptosis and cell differentiation","abstract":"<jats:title>Abstract</jats:title><jats:p>Protein translation is a critical regulatory event involved in nearly all physiological and pathological processes. Eukaryotic translation initiation factors are dedicated to translation initiation, the most highly regulated stage of protein synthesis. Eukaryotic translation initiation factor 4G2 (eIF4G2, also called p97, NAT1 and DAP5), an eIF4G family member that lacks the binding sites for 5′ cap binding protein eIF4E, is widely considered to be a key factor for internal ribosome entry sites (IRESs)‐mediated cap‐independent translation. However, recent findings demonstrate that eIF4G2 also supports many other translation initiation pathways. In this review, we summarize the role of eIF4G2 in a variety of cap‐independent and ‐dependent translation initiation events. Additionally, we also update recent findings regarding the role of eIF4G2 in apoptosis, cell survival, cell differentiation and embryonic development. These studies reveal an emerging new picture of how eIF4G2 utilizes diverse translational mechanisms to regulate gene expression.</jats:p>","journal":"Cell Proliferation","year":2023,"id":21177,"datarank":0.8614277983574834,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.3563334238595122,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.3563334238595122,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":27,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":137346,"name":"Jiuwei Cui","orcid":null,"position":1,"is_corresponding":false},{"id":137347,"name":"Andrew R. Hoffman","orcid":null,"position":2,"is_corresponding":false},{"id":137348,"name":"Ji‐Fan Hu","orcid":"0000-0002-2174-0361","position":3,"is_corresponding":false},{"id":137345,"name":"Yudi Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36547008","pmcid":"PMC9977666","openalex_id":"https://openalex.org/W4312093519","authors":[],"funders":[{"funder_name":"California Institute of Regenerative Medicine","grant_id":"RT2‐01942","title":null},{"funder_name":"Department of Finance of Jilin Province","grant_id":"JLSWSRCZX2020‐023","title":null},{"funder_name":"Department of Finance of Jilin Province","grant_id":"JLSWSRCZX2020‐100","title":null},{"funder_name":"Health Commission of Jilin Province","grant_id":"2016Q035","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31871297","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32000431","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82050003","title":null},{"funder_name":"National Science and Technology Major Project","grant_id":"2018YFA0106902","title":null},{"funder_name":"National Science and Technology Major Project","grant_id":"2020YFA0707704","title":null},{"funder_name":"U.S. Department of Veterans Affairs","grant_id":"BX002905","title":null},{"funder_name":"Department of Finance of Jilin Province","grant_id":"JLSWSRCZX2020-023","title":null},{"funder_name":"California Institute of Regenerative Medicine","grant_id":"RT2-01942","title":null},{"funder_name":"BLRD VA","grant_id":"I01 BX002905","title":null},{"funder_name":"Jilin Provincial Development and Reform Commission","grant_id":"2021C10","title":null},{"funder_name":"Department of Finance of Jilin Province","grant_id":"JLSWSRCZX2020-100","title":null}],"total_grants":15,"fwci":1.9057,"citation_percentile":0.86598486,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":7},{"year":2025,"count":12},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpr.13367","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpr.13367","host_type":"GOLD"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpr.13367","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cpr.13367","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cpr.13367","host_type":"publisher"},{"url":"https://doi.org/10.1111/cpr.13367","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36547008","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9977666","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9977666","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9977666?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["RNA and protein synthesis mechanisms","Viral Infections and Immunology Research","RNA Research and Splicing","Medicine","Biology","Apoptosis","Cell Differentiation","Eukaryotic Initiation Factor-4E","Eukaryotic Initiation Factor-4G","Protein Processing, Post-Translational","Humans","Protein Biosynthesis"],"mesh_terms":["Cell Differentiation","Humans","Protein Processing, Post-Translational","Protein Biosynthesis","Apoptosis","Eukaryotic Initiation Factor-4E","Eukaryotic Initiation Factor-4G"],"keywords":["EIF4G","EIF4E","Initiation factor","Eukaryotic translation initiation factor 4 gamma","Internal ribosome entry site","EIF4A1","Eukaryotic initiation factor","Eukaryotic translation","EIF4EBP1","Translation (biology)","Biology","Cell biology","Protein biosynthesis","Translational regulation","Computational biology","Genetics","Messenger RNA","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T14:52:21.451422Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}