{"doi":"10.1111/cob.70021","title":"Impact of maternal body mass index (<scp>BMI</scp>) and gestational weight gain on offspring's weight and <scp>BMI</scp><i>z</i>‐scores across the first 8 years of life","abstract":"Summary While prior studies have linked maternal pre‐pregnancy body mass index (BMI) and gestational weight gain (GWG) to birth weight and early childhood obesity, fewer have examined their joint effect on longitudinal growth trajectories, particularly standardized BMI z ‐scores through school age. We aimed to examine the relationship between maternal pre‐pregnancy BMI, GWG and the trajectory of offspring's early‐life weight, BMI z ‐scores and weight percentiles from birth to age 8. Linear mixed models were employed to assess the association between maternal pre‐pregnancy BMI, GWG and children's standardized weight‐for‐age, BMI and length/height‐for‐age, adjusting for potential confounders. Data were analysed from 806 mother–child pairs from the Vitamin D Antenatal Asthma Reduction Trial, with children followed longitudinally from birth through 8 years of age. Our study demonstrated a significant association between maternal pre‐pregnancy BMI and offspring weight‐for‐age and BMI z ‐score trajectories ( β = .03, 95% confidence interval [CI]: 0.02–0.04 for both; p &lt; .001, respectively). Specifically, children born to mothers with pre‐pregnancy BMI of 25–30 kg/m 2 or ≥30 kg/m 2 had significantly higher BMI z ‐scores ( β = .15, 95% CI: 0.02–0.29; p = .03; β = .49, 95% CI: 0.33–0.64; p &lt; .001, respectively) compared to those with normal BMI. Maternal BMI was not significantly associated with the child's length/height. GWG was independently and positively associated with weight‐for‐age and BMI z ‐scores ( β = .01, 95% CI: 0.002–0.015, p = .01 and β = .01, 95% CI: 0.01–0.02, p &lt; .001, respectively). Excessive GWG was linked to higher offspring weight‐for‐age and BMI z ‐scores from birth to 8 years ( β = .20, 95% CI: 0.08–0.32; β = .19, 95% CI: 0.08–0.31; p = .001, respectively) compared to guideline‐congruent or inadequate GWG. Achieving or maintaining a healthy BMI prior to pregnancy and adhering to GWG guidelines may help mitigate the risk of early childhood overweight or obesity.","journal":"Clinical Obesity","year":2025,"id":533644,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1051690,"name":"Iskander L.C. Shadid","orcid":"0000-0003-2424-5363","position":1,"is_corresponding":false},{"id":1133690,"name":"Jhill Shah","orcid":null,"position":2,"is_corresponding":false},{"id":11440,"name":"Vincent J. Carey","orcid":"0000-0003-4046-0063","position":3,"is_corresponding":false},{"id":252194,"name":"Nancy Laranjo","orcid":"0000-0002-0280-1405","position":4,"is_corresponding":false},{"id":91957,"name":"George O'connor","orcid":"0000-0002-6476-3926","position":5,"is_corresponding":false},{"id":252197,"name":"Robert S. Zeiger","orcid":"0000-0001-5788-5063","position":6,"is_corresponding":false},{"id":110400,"name":"Leonard B. Bacharier","orcid":"0000-0003-0432-2704","position":7,"is_corresponding":false},{"id":252193,"name":"Augusto A. Litonjua","orcid":"0000-0003-0422-5875","position":8,"is_corresponding":false},{"id":25033,"name":"Scott T. Weiss","orcid":"0000-0001-7196-303X","position":9,"is_corresponding":false},{"id":252195,"name":"Hooman Mirzakhani","orcid":"0000-0002-2290-4436","position":10,"is_corresponding":false},{"id":1415415,"name":"Zheng Lu","orcid":"0009-0005-2647-3011","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:51:32.301795Z","pmid":"40321144","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}