{"doi":"10.1111/cns.14586","title":"Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A\n                    <scp>NODDI</scp>\n                    study","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Objective</jats:title>\n                    <jats:p>Scarce evidence is available to elucidate the association between the abnormal microstructure of white matter (WM) and cognitive performance in patients with orthostatic hypotension (OH). This study investigated the microstructural integrity of WM in patients with mild OH (MOH) and severe OH (SOH) and evaluated the association of abnormal WM microstructure with the broad cognitive domains and cognition‐related plasma biomarkers.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Our study included 72 non‐OH (NOH), 17 MOH, and 11 SOH participants. Across the groups, the WM integrity was analyzed by neurite orientation dispersion and density imaging (NODDI), and differences in WM microstructure were evaluated by nonparametric tests and post hoc models. The correlations between WM microstructure and broad cognitive domains and cognition‐related plasma biomarkers were assessed by Spearman's correlation analysis.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      The abnormal WM microstructure was localized to the WM fiber bundles in MOH patients but distributed widely in SOH cohorts (\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05). Further analysis showed that the neurite density index of the left cingulate gyrus was negatively associated with amyloid β‐40, glial fibrillary acidic protein, neurofilament light chain, phospho‐tau181 (\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05) but positively with global cognitive function (MOCA, MMSE, AER‐III), memory, attention, language, language fluency, visuospatial function and amyloid β‐40 / amyloid β‐42 (\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05). Additionally, other abnormal WM microstructures of OH were associated with broad cognitive domains and cognition‐related plasma biomarkers to varying degrees.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>The findings evidence that abnormal WM microstructures may present themselves as early as in the MOH phase and that these structural abnormalities are associated with cognitive functions and cognition‐related plasma biomarkers.</jats:p>\n                  </jats:sec>","journal":"CNS Neuroscience &amp; Therapeutics","year":2024,"id":615975,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":585500,"name":"Lin Lin","orcid":"0000-0001-6246-8803","position":1,"is_corresponding":false},{"id":1587900,"name":"Shaofan Jiang","orcid":"0000-0001-8480-7343","position":2,"is_corresponding":false},{"id":1132588,"name":"Huang Pei-lin","orcid":"0000-0002-0411-2486","position":3,"is_corresponding":false},{"id":1587901,"name":"Jiejun Zhang","orcid":"0000-0002-1928-3624","position":4,"is_corresponding":false},{"id":1587902,"name":"Jiawei Xin","orcid":null,"position":5,"is_corresponding":false},{"id":1587903,"name":"Haibin Xu","orcid":null,"position":6,"is_corresponding":false},{"id":281598,"name":"Yanping Wang","orcid":"0000-0002-6167-4960","position":7,"is_corresponding":false},{"id":1587904,"name":"Xiaodong Pan","orcid":"0000-0001-9511-6986","position":8,"is_corresponding":false},{"id":1587899,"name":"Yingzhe Cheng","orcid":"0000-0003-1572-8689","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A\n                    <scp>NODDI</scp>\n                    study","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Objective</jats:title>\n                    <jats:p>Scarce evidence is available to elucidate the association between the abnormal microstructure of white matter (WM) and cognitive performance in patients with orthostatic hypotension (OH). This study investigated the microstructural integrity of WM in patients with mild OH (MOH) and severe OH (SOH) and evaluated the association of abnormal WM microstructure with the broad cognitive domains and cognition‐related plasma biomarkers.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Our study included 72 non‐OH (NOH), 17 MOH, and 11 SOH participants. Across the groups, the WM integrity was analyzed by neurite orientation dispersion and density imaging (NODDI), and differences in WM microstructure were evaluated by nonparametric tests and post hoc models. The correlations between WM microstructure and broad cognitive domains and cognition‐related plasma biomarkers were assessed by Spearman's correlation analysis.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      The abnormal WM microstructure was localized to the WM fiber bundles in MOH patients but distributed widely in SOH cohorts (\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05). Further analysis showed that the neurite density index of the left cingulate gyrus was negatively associated with amyloid β‐40, glial fibrillary acidic protein, neurofilament light chain, phospho‐tau181 (\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05) but positively with global cognitive function (MOCA, MMSE, AER‐III), memory, attention, language, language fluency, visuospatial function and amyloid β‐40 / amyloid β‐42 (\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05). Additionally, other abnormal WM microstructures of OH were associated with broad cognitive domains and cognition‐related plasma biomarkers to varying degrees.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>The findings evidence that abnormal WM microstructures may present themselves as early as in the MOH phase and that these structural abnormalities are associated with cognitive functions and cognition‐related plasma biomarkers.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38421091","pmcid":"PMC10851318","openalex_id":"https://openalex.org/W4391653235","authors":[],"funders":[{"funder_name":"Financial Special Project of Fujian Province","grant_id":"2021XH009","title":null},{"funder_name":"Guiding Project of Fujian Province","grant_id":"2021Y0020","title":null},{"funder_name":"Innovation of Science and Technology, Fujian Province","grant_id":"2021Y9037","title":null},{"funder_name":"National Clinical Key Special Subject of China","grant_id":"","title":null}],"total_grants":4,"fwci":3.0141,"citation_percentile":0.90830729,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14586","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14586","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cns.14586","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cns.14586","host_type":"publisher"},{"url":"https://doi.org/10.1111/cns.14586","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38421091","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10851318","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10851318/pdf/CNS-30-e14586.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10851318","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10851318?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cardiovascular Syncope and Autonomic Disorders","Obstructive Sleep Apnea Research","Heart Rate Variability and Autonomic Control"],"mesh_terms":["Brain","Humans","Hypotension, Orthostatic","Biomarkers","Amyloid beta-Peptides","Neurites","Diffusion Tensor Imaging","White Matter"],"keywords":["White matter","Orthostatic vital signs","Cognition","Medicine","Structural integrity","Internal medicine","Cardiology","Psychology","Pathology","Psychiatry","Magnetic resonance imaging","Blood pressure","Radiology","Plasma Biomarker","Wm Integrity","Moh","Soh","Noddi"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Quality Education"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T21:35:41.512608Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}