{"doi":"10.1111/cns.13824","title":"Effects of cognitive reserve proxies on cognitive function and frontoparietal control network in subjects with white matter hyperintensities: A cross‐sectional functional magnetic resonance imaging study","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>This study aimed to analyze the potential association between cognition reserve (CR) components, including education, working activity, and leisure time activity, and cognitive function in subjects with white matter hyperintensities (WMH). The study also explored the role of the frontoparietal control network (FPCN) in such association.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>White matter hyperintensities subjects with and without cognitive impairment (CI) were evaluated with multimodal magnetic resonance imaging, neuropsychological testing, and CR survey. FPCN patterns were assessed with dorsolateral prefrontal cortex seed‐based functional connectivity analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Education was positively associated with cognitive function in WMH subjects with or without CI, whereas working activity and leisure time activity were positively associated with cognitive function only in those without CI. Similarly, education was associated with bilateral FPCN in both WMH groups, whereas working activity and leisure time activity were associated with bilateral FPCN mainly in the group without CI. Furthermore, FPCN partially mediated the association between education and cognitive function in both WMH groups.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Education showed a positive impact on cognitive function in WMH subjects regardless of their cognitive status, whereas working activity and leisure time activity exhibited beneficial effects only in those without CI. The FPCN mediated the beneficial effect of education on cognitive function.</jats:p></jats:sec>","journal":"CNS Neuroscience &amp; Therapeutics","year":2022,"id":604607,"datarank":0.702693173681557,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.24601480802304357,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.24601480802304357,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":17,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1551319,"name":"Huahong Zhu","orcid":null,"position":1,"is_corresponding":false},{"id":1551320,"name":"Huiping Chen","orcid":null,"position":2,"is_corresponding":false},{"id":1326286,"name":"Renyuan Liu","orcid":null,"position":3,"is_corresponding":false},{"id":535074,"name":"Lili Huang","orcid":"0000-0001-7437-5997","position":4,"is_corresponding":false},{"id":710082,"name":"Haifeng Chen","orcid":"0000-0002-8181-7893","position":5,"is_corresponding":false},{"id":1267573,"name":"Yue Cheng","orcid":"0000-0002-1598-0959","position":6,"is_corresponding":false},{"id":285968,"name":"Ruomeng Qin","orcid":"0000-0001-7961-1602","position":7,"is_corresponding":false},{"id":693930,"name":"Pengfei Shao","orcid":"0000-0003-1249-1786","position":8,"is_corresponding":false},{"id":1551321,"name":"Hengheng Xu","orcid":null,"position":9,"is_corresponding":false},{"id":576931,"name":"Junyi Ma","orcid":"0000-0002-9369-1271","position":10,"is_corresponding":false},{"id":693931,"name":"Yun Xu","orcid":"0000-0001-5288-0319","position":11,"is_corresponding":false},{"id":751312,"name":"Qing Ye","orcid":"0000-0001-6874-5146","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of cognitive reserve proxies on cognitive function and frontoparietal control network in subjects with white matter hyperintensities: A cross‐sectional functional magnetic resonance imaging study","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>This study aimed to analyze the potential association between cognition reserve (CR) components, including education, working activity, and leisure time activity, and cognitive function in subjects with white matter hyperintensities (WMH). The study also explored the role of the frontoparietal control network (FPCN) in such association.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>White matter hyperintensities subjects with and without cognitive impairment (CI) were evaluated with multimodal magnetic resonance imaging, neuropsychological testing, and CR survey. FPCN patterns were assessed with dorsolateral prefrontal cortex seed‐based functional connectivity analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Education was positively associated with cognitive function in WMH subjects with or without CI, whereas working activity and leisure time activity were positively associated with cognitive function only in those without CI. Similarly, education was associated with bilateral FPCN in both WMH groups, whereas working activity and leisure time activity were associated with bilateral FPCN mainly in the group without CI. Furthermore, FPCN partially mediated the association between education and cognitive function in both WMH groups.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Education showed a positive impact on cognitive function in WMH subjects regardless of their cognitive status, whereas working activity and leisure time activity exhibited beneficial effects only in those without CI. The FPCN mediated the beneficial effect of education on cognitive function.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35274485","pmcid":"PMC9062549","openalex_id":"https://openalex.org/W4221093821","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81801060","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81630028","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81920108017","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2016YFC1300500‐504","title":null}],"total_grants":4,"fwci":2.1149,"citation_percentile":0.87489111,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":9},{"year":2025,"count":3},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1111/cns.13824","host_type":"journal"},{"url":"https://doi.org/10.1111/cns.13824","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cns.13824","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cns.13824","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35274485","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9062549","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9062549","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9062549?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Dementia and Cognitive Impairment Research","Functional Brain Connectivity Studies","Advanced Neuroimaging Techniques and Applications","Cognition","Cognitive Dysfunction","Cognitive Reserve","Cross-Sectional Studies","Humans","Leukoaraiosis","Magnetic Resonance Imaging","Neuropsychological Tests","White Matter"],"mesh_terms":["Cognition","Cross-Sectional Studies","Humans","Magnetic Resonance Imaging","Neuropsychological Tests","Leukoaraiosis","Cognitive Reserve","Cognitive Dysfunction","White Matter"],"keywords":["Hyperintensity","Cognitive reserve","Cognition","Functional magnetic resonance imaging","Psychology","Working memory","Neuropsychology","Association (psychology)","White matter","Effects of sleep deprivation on cognitive performance","Audiology","Dorsolateral prefrontal cortex","Magnetic resonance imaging","Frontal lobe","Cross-sectional study","Prefrontal cortex","Physical medicine and rehabilitation","Medicine","Neuroscience","Cognitive impairment","Pathology","Radiology","Education","White Matter Hyperintensities","Leisure Time Activity","Working Activity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Quality Education"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:30:41.307396Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}