{"doi":"10.1111/cea.70110","title":"Prevalence of Asymptomatic Bronchial Hyperresponsiveness in Indian Adolescents: Insights From the <scp>APEAL</scp> Study","abstract":"ABSTRACT Background Bronchial hyperresponsiveness (BHR), often undetected in asymptomatic individuals, may represent an early marker of airway inflammation and a precursor to chronic respiratory disease (CRD). Despite its established role in asthma and COPD, BHR remains under‐recognised in epidemiologic screenings, particularly in low‐ and middle‐income countries like India, where environmental exposures are high. Objective This study assessed the prevalence and burden of asymptomatic BHR in adolescents across four Indian cities: Mysuru, Bengaluru, Mumbai and Delhi, using objective airway reversibility measures. Methods This secondary analysis of the APEAL study (Air Pollution Exposure on Adolescents' Lungs) included 4141 randomly selected adolescents (11–14 years) with no reported respiratory symptoms or prior physician diagnosis of asthma. Pulmonary function tests (PFTs) assessed forced expiratory volume in 1 s (FEV 1 ) pre‐ and post‐bronchodilator. BHR was defined as post‐bronchodilator increase in FEV 1 of ≥ 12% and ≥ 200 mL. Anthropometric, socioeconomic and environmental factors were analysed. Results A total of 165 adolescents (4.0%) met criteria for asymptomatic BHR, with site‐wise variation: Mumbai (5.6%), Delhi (4.5%), Bengaluru (4.2%) and Mysuru (2.3%). Males predominated except in Delhi. Younger age was significantly associated with BHR (OR = 1.48; p = 0.035). A dose‐dependent association with PM 2.5 was observed: 64.1–124.8 μg/m 3 increased BHR risk (OR = 1.83; p = 0.033), with higher risk above 124.8 μg/m 3 (OR = 2.56; p = 0.003). In GLM analysis, Mumbai residents had lower odds of moderate (Estimate = −1.757, p = 0.048) and severe airflow limitation (Estimate = −3.200, p = 0.022) than Bengaluru. Underweight status was associated with increased risk of severe airflow limitation (Estimate =2.073, p = 0.048), while overweight appeared protective (Estimate = −14.357; p &lt; 0.001). Obesity had similar estimates (2.075) as underweight but was non‐significant due to a smaller number of subjects. Conclusion Asymptomatic BHR affects a substantial proportion of urban Indian adolescents and is associated with age, undernutrition and PM 2.5 exposure. Symptom‐based screening may miss early airway abnormalities. School‐based spirometry screening could aid in early identification of BHR and reduce long‐term CRD risk.","journal":"Clinical & Experimental Allergy","year":2025,"id":534099,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9692,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":909066,"name":"Mohammed Kaleem Ullah","orcid":"0000-0001-8470-3114","position":1,"is_corresponding":false},{"id":1314348,"name":"Mandya Venkateshmurthy Greeshma","orcid":"0000-0003-2236-4588","position":2,"is_corresponding":false},{"id":1416690,"name":"Swapnali Patil","orcid":null,"position":3,"is_corresponding":false},{"id":1416691,"name":"Priya Samdarshi","orcid":null,"position":4,"is_corresponding":false},{"id":1416692,"name":"Harshitha Veerabhadraiah","orcid":null,"position":5,"is_corresponding":false},{"id":1416693,"name":"Abdul Khayum","orcid":null,"position":6,"is_corresponding":false},{"id":1416249,"name":"Twinkle Agrawal","orcid":"0000-0003-4636-3846","position":7,"is_corresponding":false},{"id":1416250,"name":"Harish C. Phuleria","orcid":"0000-0001-5801-0015","position":8,"is_corresponding":false},{"id":647557,"name":"George D′Souza","orcid":"0000-0003-0343-4675","position":9,"is_corresponding":false},{"id":266061,"name":"Gregory A. Wellenius","orcid":"0000-0003-0427-7376","position":10,"is_corresponding":false},{"id":1034247,"name":"Amruta Nori‐Sarma","orcid":"0000-0003-2335-6811","position":11,"is_corresponding":false},{"id":1416694,"name":"Lingambika Ponnuraj","orcid":null,"position":12,"is_corresponding":false},{"id":1416695,"name":"Sanath Kumar Kagalavadi Mahadevaswamy","orcid":null,"position":13,"is_corresponding":false},{"id":1416696,"name":"Sathish Chandran Mayigaiah","orcid":null,"position":14,"is_corresponding":false},{"id":668430,"name":"Rajesh K. Thimmulappa","orcid":"0000-0001-6050-1323","position":15,"is_corresponding":false},{"id":1416251,"name":"Anant Mohan","orcid":"0000-0002-2383-9437","position":16,"is_corresponding":false},{"id":48868,"name":"P A Mahesh","orcid":"0000-0003-1632-5945","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:51:43.451278Z","pmid":"40625107","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}