{"doi":"10.1111/cea.14120","title":"Anti‐phospholipid antibodies are elevated and functionally active in chronic rhinosinusitis with nasal polyps","abstract":"BACKGROUND: Polyps from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) contain increased levels of autoreactive antibodies, B cells and fibrin deposition. Anti-phospholipid antibodies (APA) are autoantibodies known to cause thrombosis but have not been implicated in chronic rhinosinusitis (CRS). OBJECTIVE: -glycoprotein (anti-B2GP)) in nasal polyp (NP) tissue with tissue from control and CRS without nasal polyp (CRSsNP) patients, we tested whether NP antibodies affect coagulation, and correlate APAs with anti-dsDNA IgG and markers of coagulation. METHODS: Patient specimens were assayed for APA IgG, anti-dsDNA IgG and thrombin-anti-thrombin (TaT) complex by ELISA. Antibodies from a subset of specimens were tested for modified activated partial thromboplastin time (aPTT) measured on an optical-mechanical coagulometer. RESULTS: Anti-cardiolipin IgG in NP was 5-fold higher than control tissue (p < .0001). NP antibodies prolonged aPTT compared to control tissue antibodies at 400 µg/mL (36.7 s vs. 33.8 s, p = .024) and 600 µg/mL (40.9 s vs. 34.7 s, p = .0037). Anti-PE IgG antibodies were increased in NP (p = .027), but anti-B2GP IgG was not significantly higher (p = .084). All APAs correlated with anti-dsDNA IgG levels, which were also elevated (R = .77, .71 and .54, respectively, for anti-cardiolipin, anti-PE, and anti-B2GP; all p < .001), but only anti-cardiolipin (R = .50, p = .0185) and anti-PE (R = 0.45, p = .037) correlated with TaT complex levels. CONCLUSIONS: APA IgG antibodies are increased in NP and correlate with autoreactive tissue antibodies. NP antibodies have in vitro anti-coagulant activity similar to those observed in anti-phospholipid syndrome, suggesting that they may have pro-coagulant effects in polyp tissue.","journal":"Clinical & Experimental Allergy","year":2022,"id":265719,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.967,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":736499,"name":"Jeffanie Wu","orcid":"0000-0002-1125-8205","position":1,"is_corresponding":false},{"id":233265,"name":"Whitney W. Stevens","orcid":"0000-0002-2608-6610","position":2,"is_corresponding":false},{"id":848058,"name":"Junqin Bai","orcid":"0000-0001-6012-2809","position":3,"is_corresponding":false},{"id":924865,"name":"Songwang Hou","orcid":"0009-0007-3562-5341","position":4,"is_corresponding":false},{"id":710969,"name":"Julia Huang","orcid":null,"position":5,"is_corresponding":false},{"id":128474,"name":"J. Rosenberg","orcid":"0000-0002-0063-1086","position":6,"is_corresponding":false},{"id":22091,"name":"Paul J. Utz","orcid":"0000-0003-1181-1565","position":7,"is_corresponding":false},{"id":520504,"name":"Stephanie S. Smith","orcid":"0000-0002-0605-3993","position":8,"is_corresponding":false},{"id":480724,"name":"David B. Conley","orcid":"0000-0002-2611-6795","position":9,"is_corresponding":false},{"id":480725,"name":"Kevin C. Welch","orcid":"0000-0003-4863-7206","position":10,"is_corresponding":false},{"id":386199,"name":"Robert C. Kern","orcid":"0000-0002-8995-9175","position":11,"is_corresponding":false},{"id":495324,"name":"Kathryn E. Hulse","orcid":"0000-0003-0969-999X","position":12,"is_corresponding":false},{"id":233266,"name":"Anju T. Peters","orcid":"0000-0003-0745-2379","position":13,"is_corresponding":false},{"id":233260,"name":"Leslie C. Grammer","orcid":"0000-0001-6860-2014","position":14,"is_corresponding":false},{"id":761141,"name":"Ming Zhao","orcid":"0000-0003-2097-3136","position":15,"is_corresponding":false},{"id":788739,"name":"Paul F. Lindholm","orcid":"0000-0003-2498-6372","position":16,"is_corresponding":false},{"id":233264,"name":"Robert P. Schleimer","orcid":"0000-0002-8330-0097","position":17,"is_corresponding":false},{"id":348700,"name":"Bruce K. Tan","orcid":"0000-0001-9210-5050","position":18,"is_corresponding":false},{"id":893814,"name":"Jacob G. Eide","orcid":"0000-0003-3727-8287","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:26:49.862989Z","pmid":"35253284","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}