{"doi":"10.1111/cea.13776","title":"Sex‐specific associations of asthma acquisition with changes in DNA methylation during adolescence","abstract":"BACKGROUND: Underlying biological mechanisms involved in sex differences in asthma status changes from pre- to post-adolescence are unclear. DNA methylation (DNAm) has been shown to be associated with the risk of asthma. OBJECTIVE: We hypothesized that asthma acquisition from pre- to post-adolescence was associated with changes in DNAm during this period at asthma-associated cytosine-phosphate-guanine (CpG) sites and such an association was sex-specific. METHODS: Subjects from the Isle of Wight birth cohort (IOWBC) with DNAm in blood at ages 10 and 18 years (n = 124 females, 151 males) were studied. Using a training-testing approach, epigenome-wide CpGs associated with asthma were identified. Logistic regression was used to examine sex-specific associations of DNAm changes with asthma acquisition between ages 10 and 18 at asthma-associated CpGs. The ALSPAC birth cohort was used for independent replication. To assess functional relevance of identified CpGs, association of DNAm with gene expression in blood was assessed. RESULTS: ). In the replication cohort, consistent interaction effects were observed at 10 of the 13 CpGs. At 7 of these 10 CpGs, opposite DNAm changes across adolescence were observed between sexes in both cohorts. In both cohorts, cg20891917, located on IFRD1 linked to asthma, shows strong sex-specific effects on asthma transition (P-values <.01 in both cohorts). CONCLUSION AND CLINICAL RELEVANCE: Gender reversal in asthma acquisition is associated with opposite changes in DNAm (males vs females) from pre- to post-adolescence at asthma-associated CpGs. These CpGs are potential biomarkers of sex-specific asthma acquisition in adolescence.","journal":"Clinical & Experimental Allergy","year":2020,"id":101090,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9632,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":396696,"name":"Farnaz Solatikia","orcid":null,"position":1,"is_corresponding":false},{"id":282199,"name":"Hongmei Zhang","orcid":"0000-0003-3557-0364","position":2,"is_corresponding":false},{"id":496504,"name":"Alemayehu Z. Wolde","orcid":null,"position":3,"is_corresponding":false},{"id":396841,"name":"Latha Kadalayil","orcid":"0000-0002-3757-5487","position":4,"is_corresponding":false},{"id":282201,"name":"Wilfried Karmaus","orcid":"0000-0003-2684-1492","position":5,"is_corresponding":false},{"id":282191,"name":"Susan Ewart","orcid":"0000-0002-6462-7043","position":6,"is_corresponding":false},{"id":471003,"name":"Ryan Arathimos","orcid":"0000-0002-0473-500X","position":7,"is_corresponding":false},{"id":78829,"name":"Caroline Relton","orcid":"0000-0003-2052-4840","position":8,"is_corresponding":false},{"id":55351,"name":"Susan M. Ring","orcid":"0000-0003-3103-9330","position":9,"is_corresponding":false},{"id":496505,"name":"Alexander John Henderson","orcid":null,"position":10,"is_corresponding":false},{"id":247757,"name":"Syed Hasan Arshad","orcid":"0000-0001-5988-235X","position":11,"is_corresponding":false},{"id":282188,"name":"John W. Holloway","orcid":"0000-0001-9998-0464","position":12,"is_corresponding":false},{"id":496503,"name":"Rutu Rathod","orcid":null,"position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T22:39:38.259162Z","pmid":"33150670","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}