{"doi":"10.1111/cas.12019","title":"Nuclear receptor coactivator RAC3 inhibits autophagy","abstract":"<jats:p><jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 is an oncogene naturally overexpressed in several tumors. Besides its role as coactivator, it can exert several protumoral cytoplasmic actions. Autophagy was found to act either as a tumor suppressor during the early stages of tumor development, or as a protector of the tumor cell in later stages under hypoxic conditions. We found that <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 overexpression inhibits autophagy when induced by starvation or rapamycin and involves <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 nuclear translocation‐dependent and ‐independent mechanisms. Moreover, hypoxia inhibits the <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 gene expression leading to the autophagy process, allowing tumor cells to survive until angiogenesis occurs. The interplay between <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3, hypoxia, and autophagy could be an important mechanism for tumor progression and a good target for a future anticancer therapy.</jats:p>","journal":"Cancer Science","year":2012,"id":650951,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1697548,"name":"Cecilia Viviana Alvarado","orcid":null,"position":1,"is_corresponding":false},{"id":1697550,"name":"Maria Fernanda Rubio","orcid":null,"position":2,"is_corresponding":false},{"id":1697551,"name":"Marina Ruiz Grecco","orcid":null,"position":3,"is_corresponding":false},{"id":1697553,"name":"Sabrina Micenmacher","orcid":null,"position":4,"is_corresponding":false},{"id":1697555,"name":"Giselle Astrid Martinez‐Noel","orcid":null,"position":5,"is_corresponding":false},{"id":1697558,"name":"Laura Panelo","orcid":null,"position":6,"is_corresponding":false},{"id":1697559,"name":"Monica Alejandra Costas","orcid":null,"position":7,"is_corresponding":false},{"id":1697545,"name":"Pablo Nicolas Fernandez Larrosa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nuclear receptor coactivator RAC3 inhibits autophagy","abstract":"<jats:p><jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 is an oncogene naturally overexpressed in several tumors. Besides its role as coactivator, it can exert several protumoral cytoplasmic actions. Autophagy was found to act either as a tumor suppressor during the early stages of tumor development, or as a protector of the tumor cell in later stages under hypoxic conditions. We found that <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 overexpression inhibits autophagy when induced by starvation or rapamycin and involves <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 nuclear translocation‐dependent and ‐independent mechanisms. Moreover, hypoxia inhibits the <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3 gene expression leading to the autophagy process, allowing tumor cells to survive until angiogenesis occurs. The interplay between <jats:styled-content style=\"fixed-case\">RAC</jats:styled-content>3, hypoxia, and autophagy could be an important mechanism for tumor progression and a good target for a future anticancer therapy.</jats:p>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22957814","pmcid":"PMC7659320","openalex_id":"https://openalex.org/W2015044988","authors":[],"funders":[],"total_grants":0,"fwci":0.1991,"citation_percentile":0.56512957,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":1},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7659320","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7659320","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.12019","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12019","host_type":"publisher"},{"url":"https://doi.org/10.1111/cas.12019","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22957814","host_type":"repository"}],"fields_of_study":["Cancer, Hypoxia, and Metabolism","Epigenetics and DNA Methylation","RNA modifications and cancer","Autophagy","Cell Hypoxia","Cell Nucleus","Cytoplasm","Gene Expression","Genes, Tumor Suppressor","HEK293 Cells","Humans","NF-kappa B","Neoplasms","Nuclear Receptor Coactivators","rac GTP-Binding Proteins"],"mesh_terms":["Autophagy","Cell Nucleus","Cytoplasm","Humans","Neoplasms","Cell Hypoxia","Gene Expression","Genes, Tumor Suppressor","NF-kappa B","rac GTP-Binding Proteins","Nuclear Receptor Coactivators","HEK293 Cells"],"keywords":["Autophagy","Coactivator","Cancer research","Cell biology","Oncogene","Hypoxia (environmental)","Suppressor","Cytoplasm","Biology","Tumor suppressor gene","Cell","Chemistry","Gene","Transcription factor","Cell cycle","Carcinogenesis","Apoptosis","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T06:24:04.589425Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}