{"doi":"10.1111/bph.15679","title":"Sex differences in the effect of chronic delivery of the buprenorphine analogue BU08028 on heroin relapse and choice in a rat model of opioid maintenance","abstract":"BACKGROUND AND PURPOSE: Maintenance treatment with opioid agonists (buprenorphine, methadone) decreases opioid use and relapse. We recently modelled maintenance treatment in rats and found that chronic delivery of buprenorphine or the μ opioid receptor partial agonist TRV130 decreased relapse to oxycodone seeking and taking. Here, we tested the buprenorphine analogue BU08028 on different heroin relapse-related measures and heroin versus food choice. EXPERIMENTAL APPROACH: ). Effects of chronic BU08028 delivery were tested on (1) incubation of heroin-seeking in a non-drug Context B, (2) extinction responding reinforced by heroin-associated discrete cues in Context B, (3) reinstatement of heroin-seeking induced by re-exposure to Context A and (4) re-acquisition of heroin self-administration in Context A. For choice assessment, we tested the effect of chronic BU08028 delivery on heroin versus food choice. KEY RESULTS: Chronic BU08028 delivery decreased incubation of heroin seeking. Unexpectedly, BU08028 increased re-acquisition of heroin self-administration selectively in females. Chronic BU08028 had minimal effects on context-induced reinstatement and heroin versus food choice in both sexes. Finally, exploratory post hoc analyses suggest that BU08028 decreased extinction responding selectively in males. CONCLUSIONS AND IMPLICATIONS: Chronic BU08028 delivery had both beneficial and detrimental, sex-dependent, effects on different triggers of heroin relapse and minimal effects on heroin choice in both sexes. Results suggest that BU08028 would not be an effective opioid maintenance treatment in humans.","journal":"British Journal of Pharmacology","year":2021,"id":167489,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484959,"name":"E. Andrew Townsend","orcid":"0000-0002-7139-3273","position":1,"is_corresponding":false},{"id":694963,"name":"Lindsay Altidor","orcid":"0000-0003-4475-4077","position":2,"is_corresponding":false},{"id":356297,"name":"Ida Fredriksson","orcid":"0000-0002-3443-3870","position":3,"is_corresponding":false},{"id":670623,"name":"Aniruddha Shekara","orcid":"0000-0003-2392-6079","position":4,"is_corresponding":false},{"id":313535,"name":"Stephen M. Husbands","orcid":"0000-0002-9928-6322","position":5,"is_corresponding":false},{"id":415888,"name":"Agnieszka Sulima","orcid":"0000-0002-8849-9736","position":6,"is_corresponding":false},{"id":301852,"name":"Kenner C. Rice","orcid":"0000-0002-1147-9147","position":7,"is_corresponding":false},{"id":393444,"name":"Matthew L. Banks","orcid":"0000-0003-4949-5246","position":8,"is_corresponding":false},{"id":288988,"name":"Yavin Shaham","orcid":"0000-0002-8242-3319","position":9,"is_corresponding":false},{"id":355727,"name":"Jennifer M. Bossert","orcid":"0000-0001-5636-4071","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-18T23:45:58.359801Z","pmid":"34505281","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}