{"doi":"10.1111/bju.15227","title":"Cabozantinib plus docetaxel and prednisone in metastatic castration‐resistant prostate cancer","abstract":"OBJECTIVE: To evaluate the safety and efficacy of cabozantinib combined with docetaxel. PATIENTS AND METHODS: every 3 weeks with daily prednisone 10 mg) was combined with escalating doses of daily cabozantinib (20, 40 and 60 mg). Based on the results of the phase 1 study, the investigation was expanded into a randomized study of docetaxel with prednisone (hereafter 'docetaxel/prednisone') plus the maximum tolerated dose (MTD) of cabozantinib compared with docetaxel/prednisone alone. RESULTS: A total of 44 men with mCRPC were enrolled in this phase 1/2 trial. An MTD of 40 mg cabozantinib plus docetaxel/prednisone was determined. Dose-limiting toxicities were neutropenic fever and palmar-plantar erythrodysesthesia, and there was one death attributable to a thromboembolic event. In addition, grade 3 or 4 myelosuppression, hypophosphataemia and neuropathy were seen in three or more patients. In the phase 1 study, the median time to progression (TTP) and overall survival (OS) time were 13.6 and 16.3 months, respectively. In the phase 2 study, which was terminated early because of poor accrual, the median TTP and OS favoured the combination (n = 13) compared to docetaxel/prednisone alone (n = 12; 21.0 vs 6.6 months; P = 0.035 and 23.8 vs 15.6 months; P = 0.072, respectively). CONCLUSION: Despite the limited number of patients in this study, preliminary data suggest that cabozantinib can be safely added to docetaxel/prednisone with possible enhanced efficacy.","journal":"British Journal of Urology","year":2020,"id":86618,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256069,"name":"Fatima Karzai","orcid":"0000-0002-3244-1332","position":1,"is_corresponding":false},{"id":442690,"name":"Munjid Al Harthy","orcid":null,"position":2,"is_corresponding":false},{"id":441667,"name":"Daniel P. 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Dawson","orcid":null,"position":11,"is_corresponding":false},{"id":442692,"name":"Anna Couvillon","orcid":null,"position":12,"is_corresponding":false},{"id":441669,"name":"Amy Hankin","orcid":"0000-0003-3252-7854","position":13,"is_corresponding":false},{"id":442693,"name":"Moniquea Williams","orcid":null,"position":14,"is_corresponding":false},{"id":442694,"name":"Guin Chun","orcid":null,"position":15,"is_corresponding":false},{"id":410345,"name":"Helen Owens","orcid":null,"position":16,"is_corresponding":false},{"id":257287,"name":"Jennifer L. Marté","orcid":null,"position":17,"is_corresponding":false},{"id":442695,"name":"Min‐Jung Lee","orcid":null,"position":18,"is_corresponding":false},{"id":289931,"name":"Yusuke Tomita","orcid":"0000-0002-9680-7559","position":19,"is_corresponding":false},{"id":269526,"name":"Akira Yuno","orcid":null,"position":20,"is_corresponding":false},{"id":232026,"name":"Jane B. Trepel","orcid":"0000-0002-7681-6554","position":21,"is_corresponding":false},{"id":441670,"name":"Sunmin Lee","orcid":"0000-0001-9652-9475","position":22,"is_corresponding":false},{"id":109203,"name":"Seth M. Steinberg","orcid":"0000-0002-8280-551X","position":23,"is_corresponding":false},{"id":239942,"name":"James L. Gulley","orcid":"0000-0002-6569-2912","position":24,"is_corresponding":false},{"id":109200,"name":"William D. Figg","orcid":"0000-0003-2428-5613","position":25,"is_corresponding":false},{"id":263633,"name":"William L. Dahut","orcid":"0000-0002-2766-9703","position":26,"is_corresponding":false},{"id":256072,"name":"Ravi A. 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