{"doi":"10.1111/bjh.70171","title":"<i>MECOM</i> fusion partner and bone marrow blast percentage influence outcomes of patients with <i>MECOM</i> rearranged acute myeloid leukaemia","abstract":"MECOM rearrangements (MECOM-r) are acute myeloid leukaemia (AML)-defining, regardless of blast percentage or MECOM fusion partner. We sought to investigate if blast percentage or MECOM-r partner was associated with overall survival (OS). We included 152 adult patients with newly diagnosed MECOM-r and classified blast percentage into <20% or ≥20% and MECOM-r partner into classic (GATA2::MECOM) or variant (others). Thirty-one per cent had <20% blasts, with 69% having ≥20%; 57% had classic and 43% variant MECOM-r. Treatment was with intensive chemotherapy (IC) in 41% and low-intensity therapy (LIT) in 59%. Composite complete remission rates were similar between IC (50%) and LIT (48%, p = 0.99). The median OS was 17 months (95% confidence interval [CI], 12-not estimable [NE]) for <20% blasts, compared with 9 months (95% CI, 6-10) for ≥20% blasts (p < 0.01). On multivariate analysis, ≥20% blasts were associated with worse OS (hazard ratio [HR] 1.9, [95% CI, 1.2-3.2], p < 0.01), independent of age, MECOM-r partner, additional cytogenetic abnormalities, treatment intensity, addition of venetoclax and stem cell transplant (SCT). HR for IC was 2.0 (95% CI, 1.1-3.7, p = 0.03). In <20% blasts, variant MECOM-r was independently associated with a reduced hazard of death (HR 0.2 [95% CI, 0.1-0.8], p < 0.01). MECOM-r AML is a heterogenous entity; consideration should be given to LIT approaches.","journal":"British Journal of Haematology","year":2025,"id":532950,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9633,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1396798,"name":"Guojun Tang","orcid":"0000-0003-3256-740X","position":1,"is_corresponding":false},{"id":1358411,"name":"Eitan Kugler","orcid":"0009-0005-1539-1766","position":2,"is_corresponding":false},{"id":1338792,"name":"Jennifer Croden","orcid":"0000-0002-2634-4341","position":3,"is_corresponding":false},{"id":232853,"name":"Koji Sasaki","orcid":"0000-0002-9140-0610","position":4,"is_corresponding":false},{"id":981375,"name":"Alexandre Bazinet","orcid":"0000-0001-5538-4943","position":5,"is_corresponding":false},{"id":1032154,"name":"Álex Bataller","orcid":"0000-0002-6085-2745","position":6,"is_corresponding":false},{"id":232846,"name":"Guillermo Montalban‐Bravo","orcid":"0000-0002-4533-5176","position":7,"is_corresponding":false},{"id":232842,"name":"Gautam Borthakur","orcid":"0000-0001-7679-6453","position":8,"is_corresponding":false},{"id":675333,"name":"Gökçe Törüner","orcid":"0000-0002-5305-6337","position":9,"is_corresponding":false},{"id":109581,"name":"Sanam Loghavi","orcid":"0000-0001-8980-3202","position":10,"is_corresponding":false},{"id":230993,"name":"Nicholas J. Short","orcid":"0000-0002-2983-2738","position":11,"is_corresponding":false},{"id":232845,"name":"Ghayas C. Issa","orcid":"0000-0002-4339-8683","position":12,"is_corresponding":false},{"id":772918,"name":"Ian Bouligny","orcid":"0000-0002-4274-4249","position":13,"is_corresponding":false},{"id":232858,"name":"Sherry Pierce","orcid":"0000-0001-6641-7659","position":14,"is_corresponding":false},{"id":284154,"name":"Uday Popat","orcid":"0000-0002-7592-2224","position":15,"is_corresponding":false},{"id":232838,"name":"Naveen Pemmaraju","orcid":"0000-0002-1670-6513","position":16,"is_corresponding":false},{"id":230404,"name":"Elias Jabbour","orcid":"0000-0003-4465-6119","position":17,"is_corresponding":false},{"id":230408,"name":"Guillermo Garcia‐Manero","orcid":"0000-0002-3631-2482","position":18,"is_corresponding":false},{"id":230407,"name":"Kapil N. Bhalla","orcid":"0000-0001-5209-5126","position":19,"is_corresponding":false},{"id":230403,"name":"Farhad Ravandi","orcid":"0000-0002-7621-377X","position":20,"is_corresponding":false},{"id":232840,"name":"Naval Daver","orcid":"0000-0001-7103-373X","position":21,"is_corresponding":false},{"id":109577,"name":"Courtney D. DiNardo","orcid":"0000-0001-9003-0390","position":22,"is_corresponding":false},{"id":109598,"name":"Hagop M. Kantarjian","orcid":"0000-0002-1908-3307","position":23,"is_corresponding":false},{"id":232841,"name":"Tapan M. 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