{"doi":"10.1111/bjh.19442","title":"Peripheral T‐cell lymphomas expressing <scp>CD30</scp> and <scp>CD15</scp> expand the spectrum of anaplastic large cell lymphoma, <scp>ALK</scp>‐negative","abstract":"<jats:title>Summary</jats:title><jats:p>Peripheral T‐cell lymphomas (PTCL) are morphologically and biologically heterogeneous and a subset expresses CD30, including anaplastic large cell lymphomas (ALCL) and a minority of PTCL, not otherwise specified (PTCL, NOS). ALCL with ALK translocations (ALCL, ALK+) are readily identified by routine diagnostic methods, but differentiating ALCL without ALK translocation (ALCL, ALK−) and PTCL, NOS expressing CD30 (PTCL CD30+) can be challenging. Furthermore, rare PTCL co‐express CD30 and CD15 (PTCL CD30+CD15+); some resemble ALCL, ALK− while others resemble classic Hodgkin lymphoma. To explore the relationship between PTCL CD30+CD15+ and ALCL, ALK−, we analysed 19 cases of PTCL with CD30 expression, previously diagnosed as ALCL, ALK− (nine cases) and PTCL CD30+CD15+ (10 cases) for DUSP22/IRF4 rearrangements, coding RNA expression and selected transcriptome analysis using the NanoString nCounter gene expression analysis platform. Unsupervised clustering showed no clear segregation between ALCL, ALK− and PTCL CD30+CD15+. Three cases previously classified as PTCL CD30+CD15+ showed DUSP22/IRF4 rearrangements, favouring a diagnosis of ALCL, ALK−. Our results suggest that cases previously designated PTCL CD30+CD15+, likely fall within the spectrum of ALCL, ALK−; additionally, a subset of ALCL, ALK− with DUSP22/IRF4 rearrangement expresses CD15, consistent with previous reports and expands the immunophenotypic spectrum of this lymphoma subgroup.</jats:p>","journal":"British Journal of Haematology","year":2024,"id":632507,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355388,"name":"Alina Nicolae","orcid":"0000-0003-3171-0059","position":1,"is_corresponding":false},{"id":319231,"name":"Caoimhe Egan","orcid":null,"position":2,"is_corresponding":false},{"id":272482,"name":"Huimin Geng","orcid":"0000-0001-5339-5446","position":3,"is_corresponding":false},{"id":232024,"name":"Liqiang Xi","orcid":"0000-0001-5033-7072","position":4,"is_corresponding":false},{"id":204755,"name":"Svetlana D. Pack","orcid":null,"position":5,"is_corresponding":false},{"id":1073913,"name":"Jason R. McFadden","orcid":"0000-0003-3943-5768","position":6,"is_corresponding":false},{"id":127282,"name":"Mark Raffeld","orcid":null,"position":7,"is_corresponding":false},{"id":258332,"name":"Elaine S. Jaffe","orcid":"0000-0003-4632-0301","position":8,"is_corresponding":false},{"id":225661,"name":"Stefania Pittaluga","orcid":"0000-0001-7688-1439","position":9,"is_corresponding":false},{"id":1639586,"name":"Karthik A. Ganapathi","orcid":"0000-0002-6090-1973","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Peripheral T‐cell lymphomas expressing <scp>CD30</scp> and <scp>CD15</scp> expand the spectrum of anaplastic large cell lymphoma, <scp>ALK</scp>‐negative","abstract":"<jats:title>Summary</jats:title><jats:p>Peripheral T‐cell lymphomas (PTCL) are morphologically and biologically heterogeneous and a subset expresses CD30, including anaplastic large cell lymphomas (ALCL) and a minority of PTCL, not otherwise specified (PTCL, NOS). ALCL with ALK translocations (ALCL, ALK+) are readily identified by routine diagnostic methods, but differentiating ALCL without ALK translocation (ALCL, ALK−) and PTCL, NOS expressing CD30 (PTCL CD30+) can be challenging. Furthermore, rare PTCL co‐express CD30 and CD15 (PTCL CD30+CD15+); some resemble ALCL, ALK− while others resemble classic Hodgkin lymphoma. To explore the relationship between PTCL CD30+CD15+ and ALCL, ALK−, we analysed 19 cases of PTCL with CD30 expression, previously diagnosed as ALCL, ALK− (nine cases) and PTCL CD30+CD15+ (10 cases) for DUSP22/IRF4 rearrangements, coding RNA expression and selected transcriptome analysis using the NanoString nCounter gene expression analysis platform. Unsupervised clustering showed no clear segregation between ALCL, ALK− and PTCL CD30+CD15+. Three cases previously classified as PTCL CD30+CD15+ showed DUSP22/IRF4 rearrangements, favouring a diagnosis of ALCL, ALK−. Our results suggest that cases previously designated PTCL CD30+CD15+, likely fall within the spectrum of ALCL, ALK−; additionally, a subset of ALCL, ALK− with DUSP22/IRF4 rearrangement expresses CD15, consistent with previous reports and expands the immunophenotypic spectrum of this lymphoma subgroup.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38613165","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.19442","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19442","host_type":"publisher"}],"fields_of_study":["Female","Humans","Male","Anaplastic Lymphoma Kinase","Dual-Specificity Phosphatases","Gene Rearrangement","Interferon Regulatory Factors","Ki-1 Antigen","Lewis X Antigen","Lymphoma, Large-Cell, Anaplastic","Lymphoma, T-Cell, Peripheral","Mitogen-Activated Protein Kinase Phosphatases","Interferon Regulatory Factor-4"],"mesh_terms":["Female","Humans","Male","Anaplastic Lymphoma Kinase","Dual-Specificity Phosphatases","Gene Rearrangement","Interferon Regulatory Factors","Ki-1 Antigen","Lewis X Antigen","Lymphoma, Large-Cell, Anaplastic","Lymphoma, T-Cell, Peripheral","Mitogen-Activated Protein Kinase Phosphatases","Interferon Regulatory Factor-4"],"keywords":["ALK‐negative","CD15","CD30","anaplastic large cell lymphoma","peripheral T‐cell lymphoma"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:53:27.702388Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}