{"doi":"10.1111/bjh.19037","title":"Clinical efficacy and safety of chimeric antigen receptor T‐cell therapy for mantle cell lymphoma with secondary central nervous system involvement","abstract":"Data describing outcomes of chimeric antigen receptor (CAR) T-cell therapy in patients with secondary central nervous system (SCNS) involvement of mantle cell lymphoma (MCL) are limited. We identified 10 patients with MCL and SCNS involvement treated with anti-CD19 CAR T-cell therapy at three US academic centres. Frequent objective responses were observed in the CNS (86%) and systemically (90%), and the 1-year progression-free survival was 47%. Seven patients developed immune-effector-cell-associated-neurotoxicity-syndrome (n = 2 Grade 1, n = 5 Grade 3). Our results suggest that anti-CD19 CAR T-cell therapy in this setting is feasible and additional data regarding neurotoxicity in this population may be warranted.","journal":"British Journal of Haematology","year":2023,"id":340086,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9285,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":287949,"name":"Rebecca L. Zon","orcid":"0000-0002-6980-5996","position":1,"is_corresponding":false},{"id":250460,"name":"Robert Redd","orcid":"0000-0002-1329-5288","position":2,"is_corresponding":false},{"id":343821,"name":"David C. Fisher","orcid":"0000-0001-6915-8584","position":3,"is_corresponding":false},{"id":55979,"name":"Roni Shouval","orcid":"0000-0001-9827-8032","position":4,"is_corresponding":false},{"id":246209,"name":"Anita Kumar","orcid":"0000-0002-1381-5810","position":5,"is_corresponding":false},{"id":343822,"name":"Jennifer L. Crombie","orcid":"0000-0003-3445-5129","position":6,"is_corresponding":false},{"id":1075086,"name":"Hossein Sadrzadeh","orcid":null,"position":7,"is_corresponding":false},{"id":322578,"name":"Austin I. Kim","orcid":"0000-0003-1039-0658","position":8,"is_corresponding":false},{"id":238090,"name":"Lakshmi Nayak","orcid":"0000-0003-2725-8717","position":9,"is_corresponding":false},{"id":492423,"name":"Ugonma Chukwueke","orcid":"0000-0003-0598-9535","position":10,"is_corresponding":false},{"id":11101,"name":"Caron A. Jacobson","orcid":"0000-0002-0180-0654","position":11,"is_corresponding":false},{"id":268729,"name":"Matthew J. Frigault","orcid":"0000-0002-6774-5694","position":12,"is_corresponding":false},{"id":237596,"name":"M. Lia Palomba","orcid":"0000-0001-5099-9156","position":13,"is_corresponding":false},{"id":282403,"name":"Philippe Armand","orcid":"0000-0001-6098-1603","position":14,"is_corresponding":false},{"id":275371,"name":"Zachary D. Epstein‐Peterson","orcid":"0000-0002-5942-2502","position":15,"is_corresponding":false},{"id":343820,"name":"Reid W. Merryman","orcid":"0000-0002-6360-3234","position":16,"is_corresponding":false},{"id":233558,"name":"Christine E. Ryan","orcid":"0000-0003-2588-1943","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T01:10:54.145367Z","pmid":"37584155","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}