{"doi":"10.1111/bjh.18883","title":"Treatment‐free remission after dasatinib in patients with chronic myeloid leukaemia in chronic phase with deep molecular response: Final 5‐year analysis of <scp>DASFREE</scp>","abstract":"Patients with chronic myeloid leukaemia in chronic phase (CML-CP) who have a sustained deep molecular response (DMR) are eligible to discontinue treatment and attempt treatment-free remission (TFR). In the DASFREE study (ClinicalTrials.gov; NCT01850004), the 2-year TFR rate after dasatinib discontinuation was 46%; here we present the 5-year update. Patients with a stable DMR after ≥2 years of dasatinib therapy discontinued treatment and were followed for 5 years. At a minimum follow-up of 60 months, in 84 patients discontinuing dasatinib, the 5-year TFR rate was 44% (n = 37). No relapses occurred after month 39 and all evaluable patients who relapsed and restarted dasatinib (n = 46) regained a major molecular response in a median of 1.9 months. The most common adverse event during the off-treatment period was arthralgia (18%, 15/84); a total of 15 withdrawal events were reported in nine patients (11%). At the 5-year final follow-up, almost half of the patients who discontinued dasatinib after a sustained DMR maintained TFR. All evaluable patients who experienced a relapse quickly regained a DMR after restarting dasatinib, demonstrating that dasatinib discontinuation is a viable and potentially long-term option in patients with CML-CP. The safety profile is consistent with the previous report.","journal":"British Journal of Haematology","year":2023,"id":333312,"datarank":0.8660206974806853,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.3893126229284934,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.3893126229284934,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":18,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9448,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01850004"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342157,"name":"Valentín García‐Gutiérrez","orcid":"0000-0003-4752-0815","position":1,"is_corresponding":false},{"id":1060595,"name":"Antonio Jiménez‐Velasco","orcid":"0000-0001-6421-7872","position":2,"is_corresponding":false},{"id":636363,"name":"Sarah Larson","orcid":"0000-0002-4335-2925","position":3,"is_corresponding":false},{"id":595803,"name":"Susanne Saußele","orcid":"0000-0003-0357-5785","position":4,"is_corresponding":false},{"id":1060596,"name":"Delphine Réa","orcid":"0000-0001-5379-7461","position":5,"is_corresponding":false},{"id":595805,"name":"François‐Xavier Mahon","orcid":"0000-0003-1545-6775","position":6,"is_corresponding":false},{"id":1060597,"name":"Moshe Levy","orcid":"0000-0002-2570-6128","position":7,"is_corresponding":false},{"id":1060598,"name":"María Teresa Gómez‐Casares","orcid":"0000-0003-0505-5126","position":8,"is_corresponding":false},{"id":471568,"name":"Michael J. Mauro","orcid":"0000-0002-2251-4032","position":9,"is_corresponding":false},{"id":1061126,"name":"Oumar Sy","orcid":null,"position":10,"is_corresponding":false},{"id":624915,"name":"Patricia Martin‐Regueira","orcid":null,"position":11,"is_corresponding":false},{"id":1060599,"name":"Jeffrey H. Lipton","orcid":"0000-0001-7391-7168","position":12,"is_corresponding":false},{"id":714326,"name":"Neil P. Shah","orcid":"0000-0003-4398-3388","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:09:39.719497Z","pmid":"37246588","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}