{"doi":"10.1111/bjh.18677","title":"Development and validation of a patient‐reported outcome measure to assess symptom burden after chimeric antigen receptor T‐cell therapy","abstract":"This cross-sectional study aimed to develop and validate a patient-reported outcomes (PROs) assessment tool to assess symptom burden and daily functioning in patients after chimeric antigen receptor (CAR) T-cell therapy, the MD Anderson Symptom Inventory (MDASI-CAR). The items were generated based on literature review, content elicitation interviews with patients, and clinician's review. The patients completed the MDASI core and module, single-item quality-of-life (QoL) measure and Patient-Reported Outcomes Measurement Information System-29 (PROMIS-29). The psychometric validation analysis was based on the acceptability after item reduction process. The final 10 MDASI-CAR module items included tremors, fever/chills, headache, balance, dizziness, attention, difficulty speaking, coughing, sexual dysfunction, and diarrhoea with high internal consistency (Cronbach's alpha: MDASI Core, 0.865; MDASI Interference, 0.915; CAR-T module, 0.746). The MDASI-CAR has excellent known-group validity that was demonstrated by differentiate patients based on patient's performance status (Cohen's d for MDASI core = -1.008, interference = -0.771, module = -0.835). Criterion validity was demonstrated by the significant correlations between the MDASI-CAR composite score, the single QoL item and the relevant domains on PROMIS-29 (all p < 0.05). This study established the MDASI-CAR module as a reliable and valid PRO tool for monitoring symptom burden after CAR T-cell therapy in patients with haematological malignancies. The findings need to be validated with a longitudinal design.","journal":"British Journal of Haematology","year":2023,"id":336871,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9208,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":652227,"name":"Samer A. Srour","orcid":"0000-0002-6693-2025","position":1,"is_corresponding":false},{"id":296216,"name":"Tito R. Mendoza","orcid":"0000-0001-8122-5233","position":2,"is_corresponding":false},{"id":307379,"name":"Meagan Whisenant","orcid":"0000-0002-9791-1227","position":3,"is_corresponding":false},{"id":437265,"name":"Ishwaria M. Subbiah","orcid":"0000-0002-0758-7911","position":4,"is_corresponding":false},{"id":73356,"name":"Elizabeth M. Gonzalez","orcid":"0000-0001-6424-1522","position":5,"is_corresponding":false},{"id":372232,"name":"Mona Kamal","orcid":"0000-0003-1626-2657","position":6,"is_corresponding":false},{"id":1067821,"name":"Shu‐En Shen","orcid":"0000-0002-7578-5397","position":7,"is_corresponding":false},{"id":234755,"name":"Charles S. Cleeland","orcid":"0000-0002-1460-6527","position":8,"is_corresponding":false},{"id":104772,"name":"Partow Kebriaei","orcid":"0000-0002-8607-9404","position":9,"is_corresponding":false},{"id":18376,"name":"Katayoun Rezvani","orcid":"0000-0002-9599-2246","position":10,"is_corresponding":false},{"id":11096,"name":"Sattva S. Neelapu","orcid":"0000-0003-1045-4914","position":11,"is_corresponding":false},{"id":247184,"name":"Sairah Ahmed","orcid":"0000-0001-7302-8299","position":12,"is_corresponding":false},{"id":18375,"name":"Elizabeth J. Shpall","orcid":"0000-0003-3947-4126","position":13,"is_corresponding":false},{"id":493915,"name":"Xin Shelley Wang","orcid":"0000-0003-2348-8005","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T01:10:21.947540Z","pmid":"36733986","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}