{"doi":"10.1111/bjh.18437","title":"Extended vincristine and dexamethasone pulse therapy may not be necessary for children with <scp><i>TCF3‐PBX1</i></scp> positive acute lymphoblastic leukaemia","abstract":"The effect of prolonged pulse therapy with vincristine and dexamethasone (VD) during maintenance therapy on the outcome of paediatric patients with TCF3-PBX1 positive acute lymphoblastic leukaemia (ALL) remains uncertain. We conducted non-inferiority analysis of 263 newly diagnosed TCF3-PBX1 positive ALL children who were stratified and randomly assigned (1:1) to receive seven additional VD pulses (the control group) or not (the experimental group) in the CCCG-ALL-2015 clinical trial from January 2015 to December 2019 (ChiCTR-IPR-14005706). There was no significant difference in baseline characteristics between the two groups. With a median follow-up of 4.2 years, the 5-year event-free survival (EFS) and 5-year overall survival (OS) in the control group were 90.1% (95% confidence interval [CI] 85.1-95.4) and 94.7% (95% CI, 90.9-98.6) comparable to those in the experimental group 89.2% (95% CI 84.1-94.7) and 95.6% (95% CI 91.8-99.6), respectively. Non-inferiority was established as a one-sided 95% upper confidence bound for the difference in probability of 5-year EFS was 0.003, and that for 5-year OS was 0.01 by as-treated analysis. Thus, omission of pulse therapy with VD beyond one year of treatment did not affect the outcome of children with TCF3-PBX1 positive ALL.","journal":"British Journal of Haematology","year":2022,"id":295809,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9658,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":525425,"name":"Honghong Zhang","orcid":"0000-0002-3893-5763","position":1,"is_corresponding":false},{"id":291057,"name":"Li Zhang","orcid":"0000-0002-9386-8938","position":2,"is_corresponding":false},{"id":901930,"name":"Jiaoyang Cai","orcid":"0000-0003-2051-4044","position":3,"is_corresponding":false},{"id":982031,"name":"Jie Yu","orcid":"0000-0002-1103-2679","position":4,"is_corresponding":false},{"id":982032,"name":"Shaoyan Hu","orcid":"0000-0002-3386-6957","position":5,"is_corresponding":false},{"id":982033,"name":"Yongjun Fang","orcid":"0000-0002-1081-6471","position":6,"is_corresponding":false},{"id":982034,"name":"Ju Gao","orcid":"0009-0003-4765-4554","position":7,"is_corresponding":false},{"id":360959,"name":"Hua Jiang","orcid":"0000-0002-4552-0785","position":8,"is_corresponding":false},{"id":982035,"name":"Minghua Yang","orcid":"0000-0003-3746-1209","position":9,"is_corresponding":false},{"id":982513,"name":"Changda Liang","orcid":null,"position":10,"is_corresponding":false},{"id":982036,"name":"Runming Jin","orcid":"0000-0002-7233-0354","position":11,"is_corresponding":false},{"id":982037,"name":"Xin Tian","orcid":"0000-0001-9601-3751","position":12,"is_corresponding":false},{"id":982038,"name":"Xiuli Ju","orcid":"0000-0001-5464-3106","position":13,"is_corresponding":false},{"id":982039,"name":"Qun Hu","orcid":"0000-0002-1508-2796","position":14,"is_corresponding":false},{"id":982040,"name":"Hui Jiang","orcid":"0000-0001-7624-0607","position":15,"is_corresponding":false},{"id":389867,"name":"Hui Li","orcid":"0000-0002-8438-0287","position":16,"is_corresponding":false},{"id":982514,"name":"Ningling Wang","orcid":null,"position":17,"is_corresponding":false},{"id":982041,"name":"Lirong Sun","orcid":"0000-0003-1724-5146","position":18,"is_corresponding":false},{"id":982042,"name":"Alex Wing Kwan Leung","orcid":"0000-0001-9781-5908","position":19,"is_corresponding":false},{"id":982043,"name":"Xuedong Wu","orcid":"0009-0001-7612-1429","position":20,"is_corresponding":false},{"id":982044,"name":"Junxia Wang","orcid":"0000-0001-9504-8602","position":21,"is_corresponding":false},{"id":262387,"name":"Chi Kong Li","orcid":"0000-0002-2810-5758","position":22,"is_corresponding":false},{"id":107683,"name":"Jun J. 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