{"doi":"10.1111/bjh.17984","title":"Long‐term efficacy of first‐line ibrutinib treatment for chronic lymphocytic leukaemia in patients with <i>TP53</i> aberrations: a pooled analysis from four clinical trials","abstract":"TP53 aberrations [del(17p) or TP53 mutation] predict poor survival with chemoimmunotherapy in patients with chronic lymphocytic leukaemia (CLL). We evaluated long-term efficacy and safety of first-line ibrutinib-based therapy in patients with CLL bearing TP53 aberrations in a pooled analysis across four studies: PCYC-1122e, RESONATE-2 (PCYC-1115/16), iLLUMINATE (PCYC-1130) and ECOG-ACRIN E1912. The pooled analysis included 89 patients with TP53 aberrations receiving first-line treatment with single-agent ibrutinib (n = 45) or ibrutinib in combination with an anti-CD20 antibody (n = 44). All 89 patients had del(17p) (53% of 89 patients) and/or TP53 mutation (91% of 58 patients with TP53 sequencing results available). With a median follow-up of 49·8 months (range, 0·1-95·9), median progression-free survival was not reached. Progression-free survival rate and overall survival rate estimates at four years were 79% and 88%, respectively. Overall response rate was 93%, including complete response in 39% of patients. No new safety signals were identified in this analysis. Forty-six percent of patients remained on ibrutinib treatment at last follow-up. With median follow-up of four years (up to eight years), results from this large, pooled, multi-study data set suggest promising long-term outcomes of first-line ibrutinib-based therapy in patients with TP53 aberrations. Registered at ClinicalTrials.gov (NCT01500733, NCT01722487, NCT02264574 and NCT02048813).","journal":"British Journal of Haematology","year":2021,"id":154338,"datarank":2.1868634687466404,"base_score":4.174387269895637,"endowment":4.174387269895637,"self_citation_contribution":0.6261580904843456,"citation_network_contribution":1.5607053782622946,"self_endowment_contribution":0.6261580904843456,"citer_contribution":1.5607053782622946,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":59,"citers_with_citation_signal":44,"citers_with_endowment":44,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9659,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01722487","NCT02264574","NCT02048813","NCT01500733"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":285630,"name":"Tait D. Shanafelt","orcid":"0000-0002-7106-5202","position":1,"is_corresponding":false},{"id":233559,"name":"Adrian Wiestner","orcid":"0000-0002-3533-2924","position":2,"is_corresponding":false},{"id":535516,"name":"Carol Moreno","orcid":"0000-0003-3275-0271","position":3,"is_corresponding":false},{"id":250001,"name":"Susan O’Brien","orcid":"0000-0002-2481-7504","position":4,"is_corresponding":false},{"id":653928,"name":"Jianling Li","orcid":"0000-0001-6074-8852","position":5,"is_corresponding":false},{"id":653929,"name":"Gabriel Krigsfeld","orcid":"0000-0003-4002-3699","position":6,"is_corresponding":false},{"id":250000,"name":"James P. Dean","orcid":"0000-0001-8058-1682","position":7,"is_corresponding":false},{"id":233544,"name":"Inhye E. Ahn","orcid":"0000-0003-3717-287X","position":8,"is_corresponding":false},{"id":233535,"name":"John N. Allan","orcid":"0000-0002-2088-0899","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T23:43:49.684414Z","pmid":"34865212","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}