{"doi":"10.1111/bjh.17450","title":"Comparison of immunohistochemistry and gene expression profiling subtyping for diffuse large B‐cell lymphoma in the phase III clinical trial of R‐CHOP ± ibrutinib","abstract":"We assessed the concordance between immunohistochemistry (IHC) and gene expression profiling (GEP) for determining diffuse large B-cell lymphoma (DLBCL) cell of origin (COO) in the phase III PHOENIX trial of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) with or without ibrutinib. Among 910 of 1114 screened patients with non-germinal centre B cell-like (non-GCB) DLBCL by IHC, the concordance with GEP for non-GCB calls was 82·7%, with 691 (75·9%) identified as activated B cell-like (ABC), and 62 (6·8%) as unclassified. Among 746 of 837 enrolled patients with verified non-GCB DLBCL by IHC, the concordance with GEP was 82·8%, with 567 (76·0%) identified as ABC and 51 (6·8%) unclassified; survival outcomes were similar regardless of COO or treatment, whereas among patients with ABC DLBCL aged <60 years, the overall and event-free survival were substantially better with ibrutinib versus placebo plus R-CHOP [hazard ratio (HR) 0·365, 95% confidence interval (CI) 0·147-0·909, P = 0·0305; HR 0·561, 95% CI 0·326-0·967, P = 0·0348, respectively]. IHC and GEP showed high concordance and consistent survival outcomes among tested patients, indicating centralised IHC may be used to enrich populations for response to ibrutinib plus R-CHOP.","journal":"British Journal of Haematology","year":2021,"id":183878,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9338,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":738269,"name":"Songbai Wang","orcid":"0000-0002-0079-1397","position":1,"is_corresponding":false},{"id":739035,"name":"Christopher Major","orcid":null,"position":2,"is_corresponding":false},{"id":619803,"name":"Brendan P. Hodkinson","orcid":null,"position":3,"is_corresponding":false},{"id":738270,"name":"Michael Schäffer","orcid":"0000-0003-1381-0275","position":4,"is_corresponding":false},{"id":296279,"name":"Laurie H. Sehn","orcid":"0000-0003-1860-9765","position":5,"is_corresponding":false},{"id":567386,"name":"Peter Johnson","orcid":"0000-0003-2306-4974","position":6,"is_corresponding":false},{"id":488588,"name":"Pier Luigi Zinzani","orcid":"0000-0002-2112-2651","position":7,"is_corresponding":false},{"id":739036,"name":"Jodi Carey","orcid":null,"position":8,"is_corresponding":false},{"id":739037,"name":"S. Martin Shreeve","orcid":null,"position":9,"is_corresponding":false},{"id":738271,"name":"Steven Sun","orcid":"0000-0003-4603-2043","position":10,"is_corresponding":false},{"id":490408,"name":"John F. Gerecitano","orcid":"0000-0002-9300-9287","position":11,"is_corresponding":false},{"id":229929,"name":"Jessica Vermeulen","orcid":null,"position":12,"is_corresponding":false},{"id":35688,"name":"Louis M. Staudt","orcid":"0000-0002-1735-2892","position":13,"is_corresponding":false},{"id":35694,"name":"Wyndham H. Wilson","orcid":"0000-0002-2862-9711","position":14,"is_corresponding":false},{"id":618795,"name":"Sriram Balasubramanian","orcid":"0000-0003-2018-2094","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-18T23:48:26.340498Z","pmid":"33942292","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}