{"doi":"10.1111/apha.13448","title":"Electrolyte and transporter responses to angiotensin II induced hypertension in female and male rats and mice","abstract":"Abstract Aim Sexual dimorphisms are evident along the nephron: Females (F) exhibit higher ratios of renal distal to proximal Na + transporters' abundance, greater lithium clearance (C Li ) more rapid natriuresis in response to saline infusion and lower plasma [K + ] vs. males (M). During angiotensin II infusion hypertension (AngII‐HTN) M exhibit distal Na + transporter activation, lower proximal and medullary loop transporters, blunted natriuresis in response to saline load, and reduced plasma [K + ]. This study aimed to determine whether responses of F to AngII‐HTN mimicked those in M or were impacted by sexual dimorphisms evident at baseline. Methods Sprague Dawley rats and C57BL/6 mice were AngII infused via osmotic minipumps 2 and 3 weeks, respectively, and assessed by metabolic cage collections, tail‐cuff sphygmomanometer, semi‐quantitative immunoblotting of kidney and patch‐clamp electrophysiology. Results In F rats, AngII‐infusion increased BP to 190 mm Hg, increased phosphorylation of cortical NKCC2, NCC and cleavage of ENaC two to threefold, increased ENaC channel activity threefold and aldosterone 10‐fold. K + excretion increased and plasma [K + ] decreased. Evidence of natriuresis in F included increased urine Na + excretion and C Li , and decreased medullary NHE3, NKCC2 and Na,K‐ATPase abundance. In C57BL/6 mice, AngII‐HTN increased abundance of distal Na + transporters, suppressed proximal‐medullary transporters and reduced plasma [K + ] in both F and M. Conclusion Despite baseline sexual dimorphisms, AngII‐HTN provokes similar increases in BP, aldosterone, distal transporters, ENaC channel activation and K + loss accompanied by similar suppression of proximal and loop Na + transporters, natriuresis and diuresis in females and males.","journal":"Acta Physiologica","year":2020,"id":66765,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353655,"name":"Brandon E. McFarlin","orcid":"0000-0003-3829-4609","position":1,"is_corresponding":false},{"id":354829,"name":"Donna L. Ralph","orcid":null,"position":2,"is_corresponding":false},{"id":353656,"name":"Vadym Buncha","orcid":"0000-0002-8582-6957","position":3,"is_corresponding":false},{"id":354830,"name":"Jessica Prescott","orcid":null,"position":4,"is_corresponding":false},{"id":354831,"name":"Borna S. Shirvani","orcid":null,"position":5,"is_corresponding":false},{"id":353657,"name":"Jillian C. McDonough","orcid":"0000-0002-0461-585X","position":6,"is_corresponding":false},{"id":353658,"name":"Darren Ha","orcid":"0000-0003-1701-9755","position":7,"is_corresponding":false},{"id":323111,"name":"Jorge F. Giani","orcid":"0000-0003-0481-6595","position":8,"is_corresponding":false},{"id":302359,"name":"Susan B. Gurley","orcid":"0000-0002-2659-6485","position":9,"is_corresponding":false},{"id":353659,"name":"Mykola Mamenko","orcid":"0000-0001-8683-0715","position":10,"is_corresponding":false},{"id":353660,"name":"Alicia A. McDonough","orcid":"0000-0002-0459-469X","position":11,"is_corresponding":false},{"id":323109,"name":"Luciana C. Veiras","orcid":"0000-0002-4635-7772","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:14:50.590588Z","pmid":"31994810","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}