{"doi":"10.1111/aor.15023","title":"The Role of Scalp <scp>EEG</scp> Recordings During Cortical Visual Prosthesis Testing","abstract":"INTRODUCTION: This article highlights the value of recording scalp electroencephalogram (EEG) from two individuals with blindness who received intracortical visual stimulators to create artificial vision. Given the known risk of cortical stimulation inducing seizures, we recorded occipital scalp EEG as a safety precaution. Over a 3-year period, over 330 h of EEG data were collected. METHODS: Twenty-five wireless floating microelectrode arrays (WFMAs), each containing 16 stimulating electrodes, were implanted in the right dorsolateral occipital cortex of the first participant, totaling 400 independently controlled stimulating electrodes. Similarly, 32 WFMAs were implanted in the second participant's cortex, totaling 512 electrodes. Phosphenes were characterized and mapped to align their locations in the visual field to create camera-driven imagery of the visual environment. RESULTS: Scalp EEG recordings during intracortical stimulation provided early warning of impending epileptic activity, reducing the risk of stimulation-induced seizures. In two instances, seizures occurred during direct cortical stimulation and were visible in the scalp EEG recordings. Normal electrically evoked potentials (eEPs) were also evident in the EEG records. CONCLUSION: Scalp EEG can be valuable to alert researchers to impending seizures. However, it is not required for conditions in which low levels of stimulation are employed. TRIAL REGISTRATION: Clinical Trial Number NCT04634383.","journal":"Artificial Organs","year":2025,"id":525848,"datarank":0.20986956300287235,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.001925408834888737,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.001925408834888737,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6052,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04634383"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":481390,"name":"Philip R. Troyk","orcid":"0000-0002-6219-175X","position":1,"is_corresponding":false},{"id":733607,"name":"Gislin Dagnelie","orcid":"0000-0001-6707-9735","position":2,"is_corresponding":false},{"id":424452,"name":"Stuart F. Cogan","orcid":"0000-0001-6316-3032","position":3,"is_corresponding":false},{"id":692641,"name":"Michael P. Barry","orcid":"0000-0002-0566-2383","position":4,"is_corresponding":false},{"id":1401369,"name":"Patricia Grant","orcid":null,"position":5,"is_corresponding":false},{"id":1401370,"name":"Frank Lane","orcid":null,"position":6,"is_corresponding":false},{"id":1401371,"name":"Janet P. Szlyk","orcid":null,"position":7,"is_corresponding":false},{"id":1401372,"name":"Maggie McNulty","orcid":null,"position":8,"is_corresponding":false},{"id":825562,"name":"Wim van Drongelen","orcid":"0000-0001-8950-5424","position":9,"is_corresponding":false},{"id":1401373,"name":"Tuan H. Pham","orcid":null,"position":10,"is_corresponding":false},{"id":1401374,"name":"Kelsey Stipp","orcid":null,"position":11,"is_corresponding":false},{"id":1401375,"name":"Meesa Royster","orcid":null,"position":12,"is_corresponding":false},{"id":417991,"name":"Vernon L. Towle","orcid":"0000-0002-2166-5496","position":13,"is_corresponding":false},{"id":1401368,"name":"Katarina Stephan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:50:25.860105Z","pmid":"40421717","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}