{"doi":"10.1111/aor.14446","title":"Early initiation of physical and occupational therapy while on extracorporeal life support improves patients' functional activity","abstract":"PURPOSE: Managing acute respiratory distress syndrome (ARDS) patients on venovenous extracorporeal membrane oxygenation (V-V ECMO), without sedation/neuromuscular blockade to allow physical and occupational therapy (PT/OT) participation, is untraditional. Here, we investigate the impact of early PT/OT initiation on discharge functional activity for ARDS patients managed on V-V ECMO. METHODS: This is a retrospective review of 67 ARDS patients managed with V-V ECMO at a single academic center from February 2018 to June 2021. Data collected included patient characteristics, days of V-V ECMO support, day of PT/OT initiation, and ambulation distance and Activity Measure for Post-Acute Care (AMPAC) Six-Clicks score on day of discharge. RESULTS: Patients with >7 days of V-V ECMO support had decreased ambulation and AMPAC scores compared to those with <7 days (70.5 vs. 162.1, p < 0.01 and 12.3 vs. 16.4, p = 0.01, respectively). PT/OT initiation within 7 days after starting V-V ECMO significantly improved ambulation and AMPAC scores (163.5 vs. 59.5, p < 0.001, and 16.6 vs. 11.8, p < 0.01, respectively). Additionally, in patients with >7 days of V-V ECMO support, those who began PT/OT within 8 days of V-V ECMO cannulation had significantly improved ambulation and AMPAC scores (151.8 vs. 44.2, p < 0.01, and 16.5 vs. 11.0, p < 0.01, respectively). CONCLUSION: Early PT/OT initiation in severe ARDS patients managed on V-V ECMO is associated with improved patient functional activity on day of discharge. Our study further supports the use of V-V ECMO in treatment of severe ARDS without sedation/neuromuscular blockade and specifically demonstrates PT/OT should be started early following V-V ECMO cannulation.","journal":"Artificial Organs","year":2022,"id":274583,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9624,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":232811,"name":"Adwaiy Manerikar","orcid":"0000-0002-7648-8888","position":1,"is_corresponding":false},{"id":895996,"name":"Viswajit Kandula","orcid":"0000-0002-2245-5845","position":2,"is_corresponding":false},{"id":943660,"name":"Tara Nykiel","orcid":null,"position":3,"is_corresponding":false},{"id":943661,"name":"Shelby Lane","orcid":null,"position":4,"is_corresponding":false},{"id":943662,"name":"Rebecca Gabaldon","orcid":null,"position":5,"is_corresponding":false},{"id":943119,"name":"Takahide Toyoda","orcid":"0000-0003-4766-5221","position":6,"is_corresponding":false},{"id":943120,"name":"Yuriko Yagi","orcid":"0000-0002-2858-1463","position":7,"is_corresponding":false},{"id":232806,"name":"Ankit Bharat","orcid":"0000-0002-1248-0457","position":8,"is_corresponding":false},{"id":232809,"name":"Chitaru Kurihara","orcid":"0000-0003-3536-4675","position":9,"is_corresponding":false},{"id":651155,"name":"Emily Cerier","orcid":"0000-0002-0095-2592","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T00:28:12.324621Z","pmid":"36310407","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}