{"doi":"10.1111/andr.70056","title":"A North American preconception cohort study of cannabis use and semen quality","abstract":"BACKGROUND: Recreational and medicinal use of cannabis is increasing among North American reproductive-aged couples. Studies of cannabis use and semen quality are limited and have produced inconsistent findings. OBJECTIVES: We examined the association between male cannabis use and semen parameters. MATERIALS AND METHODS: We analyzed data from 1654 semen samples contributed by 921 male participants in Pregnancy Study Online (PRESTO), a North American preconception cohort study. Participants aged ≥21 years completed a baseline questionnaire on which they reported their cannabis use within the past 2 months. After enrollment, we invited participants to perform at-home semen testing. We used linear regression to estimate percent differences in mean semen parameter values (%D) and 95% confidence intervals (CI) for associations between cannabis use and semen volume (mL), total sperm count (TSC, million), sperm concentration (million/mL), motility (%), and total motile sperm count (TMSC, million), controlling for potential confounders. We used log-binomial regression to estimate risk ratios (RRs) for low semen quality based on 2021 World Health Organization cut-points. RESULTS: Overall, 22.6% of participants reported current cannabis use and 3.3% reported daily use. Nearly 6% of participants had low semen volume (≤1.5 mL), 13% low sperm concentration (≤15 million/L), 8% low TSC (≤39 million), 25% low sperm motility (≤40%), and 11% low TMSC (≤16 million). Adjusted %Ds (95% CIs) comparing current cannabis use versus non-use were -3.2 (-9.1, 2.7) for semen volume, 3.5 (-10.3, 19.5) for sperm concentration, -0.6 (-14.3, 15.3) for TSC, 2.5 (-2.9, 8.0) for motility, and 3.0 (-13.4, 22.4) for TMSC. Cannabis use ≥1 times/week (vs. non-use) was associated with low semen volume (RR = 2.16, 95% CI = 0.93-5.04). Associations were imprecise and showed no monotonic association between frequency of cannabis use and the semen parameters evaluated. CONCLUSION: In this North American preconception cohort study, current cannabis use was not appreciably associated with semen quality.","journal":"Andrology","year":2025,"id":532336,"datarank":0.21927444461944426,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.011330290451460643,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.011330290451460643,"corpus_percentile":37.23988551094608,"corpus_rank":8114,"citation_count":3,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7602,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1291233,"name":"Dmitrii Krivorotko","orcid":null,"position":1,"is_corresponding":false},{"id":1068993,"name":"Martha R. Koenig","orcid":null,"position":2,"is_corresponding":false},{"id":371912,"name":"Amelia K. Wesselink","orcid":"0000-0002-3929-4451","position":3,"is_corresponding":false},{"id":232339,"name":"Michael L. Eisenberg","orcid":"0000-0001-5482-0141","position":4,"is_corresponding":false},{"id":726818,"name":"Greg J. Sommer","orcid":"0000-0002-3867-7100","position":5,"is_corresponding":false},{"id":5904,"name":"Kenneth J. Rothman","orcid":"0000-0003-2398-1705","position":6,"is_corresponding":false},{"id":1413520,"name":"Sherri O. Stuver","orcid":"0000-0002-4027-2663","position":7,"is_corresponding":false},{"id":371913,"name":"Elizabeth E. Hatch","orcid":"0000-0001-7901-3928","position":8,"is_corresponding":false},{"id":329832,"name":"Lauren A. Wise","orcid":"0000-0003-2138-3752","position":9,"is_corresponding":false},{"id":1413915,"name":"Marlon D. Joseph","orcid":null,"position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T02:51:23.237536Z","pmid":"40326424","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}