{"doi":"10.1111/and.14455","title":"<scp>IL</scp>\n            ‐17 exacerbates experimental autoimmune prostatitis via\n            <scp>CXCL1</scp>\n            /\n            <scp>CXCL2</scp>\n            ‐mediated neutrophil infiltration","abstract":null,"journal":"Andrologia","year":2022,"id":668422,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":393268,"name":"Jia Chen","orcid":"0000-0001-6608-1518","position":1,"is_corresponding":false},{"id":1225951,"name":"Hui Wang","orcid":"0000-0002-0593-6380","position":2,"is_corresponding":false},{"id":638000,"name":"Jing Chen","orcid":"0000-0001-6321-0505","position":3,"is_corresponding":false},{"id":1745464,"name":"Mei‐Juan Zheng","orcid":null,"position":4,"is_corresponding":false},{"id":1745465,"name":"Xian‐Guo Chen","orcid":null,"position":5,"is_corresponding":false},{"id":752180,"name":"Li Zhang","orcid":"0000-0001-5705-6548","position":6,"is_corresponding":false},{"id":1745466,"name":"Chao‐Zhao Liang","orcid":"0000-0003-2317-1323","position":7,"is_corresponding":false},{"id":1745467,"name":"Chang‐Sheng Zhan","orcid":null,"position":8,"is_corresponding":false},{"id":788925,"name":"Cheng Zhang","orcid":"0000-0003-4406-2046","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<scp>IL</scp>\n            ‐17 exacerbates experimental autoimmune prostatitis via\n            <scp>CXCL1</scp>\n            /\n            <scp>CXCL2</scp>\n            ‐mediated neutrophil infiltration","abstract":"Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a poorly understood disease. Accumulating evidence suggests that autoimmune dysfunction is involved in the development of CP/CPPS. Interleukin-17 (IL-17) is associated with the occurrence and development of several chronic autoimmune inflammatory diseases. However, the molecular mechanisms underlying the role of IL-17 in CP/CPPS are not clear. We confirmed that IL-17 was increased in the prostate tissues of experimental autoimmune prostatitis (EAP) mice. Corresponding to the increase of IL-17, neutrophil infiltration and the levels of CXCL1 and CXCL2 (CXC chemokine ligands 1 and 2) were also increased in the prostate of EAP. Treatment of EAP mice with an IL-17-neutralizing monoclonal antibody (mAb) decreased the number of infiltrated neutrophils and CXCL1 and CXCL2 levels. Depletion of neutrophils using anti-Ly6G antibodies ameliorated the inflammatory changes and hyperalgesia caused by EAP. Fucoidan, a could potent inhibitor of neutrophil migration, also ameliorate the manifestations of EAP. Our findings suggested that IL-17 promoted the production of CXCL1 and CXCL2, which triggered neutrophil chemotaxis to prostate tissues. Fucoidan might be a potential drug for the treatment of EAP via the effective inhibition of neutrophil infiltration.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35560069","pmcid":null,"openalex_id":"https://openalex.org/W4280532224","authors":[],"funders":[{"funder_name":"Natural Science Foundation of Anhui Province","grant_id":"2008085QH360","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82000720","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81630019","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81870519","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81970597","title":null}],"total_grants":5,"fwci":2.3008,"citation_percentile":0.88965373,"influential_citations":0,"citation_trend":[{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":6},{"year":2026,"count":8}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/and.14455","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/and.14455","host_type":"publisher"},{"url":"https://doi.org/10.1111/and.14455","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35560069","host_type":"repository"}],"fields_of_study":["Urticaria and Related Conditions","Dermatology and Skin Diseases","Pain Mechanisms and Treatments"],"mesh_terms":["Animals","Autoimmune Diseases","Chronic Disease","Disease Models, Animal","Humans","Male","Prostatitis","Pelvic Pain","Interleukin-17","Neutrophil Infiltration","Mice","Chemokine CXCL1","Chemokine CXCL2","Chronic Pain"],"keywords":["CXCL1","CXCL2","Chemokine","Immunology","Prostatitis","Medicine","CCL3","CXC chemokine receptors","Inflammation","Monoclonal antibody","Antibody","Prostate","CCL2","Internal medicine","Chemokine receptor","Il-17","Neutrophil Infiltration","Experimental Autoimmune Prostatitis","Cxcl1/cxcl2"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-14T11:09:47.774791Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}