{"doi":"10.1111/all.16500","title":"Point‐of‐Care Blood Eosinophils to Predict Preschool Wheeze Attacks","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:sec>\n                    <jats:title>Background</jats:title>\n                    <jats:p>Post hoc analysis of clinical trials shows blood eosinophil counts (BEC) predict future preschool wheeze attacks; however, prospective usefulness in a clinical setting is unreported. We assessed the feasibility of point‐of‐care (POC) eosinophil measurements in preschool wheezers and related BEC to symptoms, lung function, and utility in predicting attacks.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Children aged 1–5 years with recurrent wheeze underwent finger‐prick sampling during the outpatient clinic for POC eosinophils, forced oscillation technique (FOT) and/or spirometry, and symptom score (TRACK questionnaire). The utility of BEC and/or the other tests in predicting wheeze attacks in the subsequent 3 months was analysed by comparing those with and without an attack and using a predictive decision tree (DT) model.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      Seventy‐three children (median age 4.27 years) were recruited; BEC were higher in atopic children (median 0.5 × 10\n                      <jats:sup>9</jats:sup>\n                      /L vs. 0.3 × 10\n                      <jats:sup>9</jats:sup>\n                      /L non‐atopic,\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.01). BEC moderately correlated with FOT reactance bronchodilator reversibility\n                      <jats:italic>z</jats:italic>\n                      ‐score changes (\n                      <jats:italic>r</jats:italic>\n                       = 0.495,\n                      <jats:italic>p</jats:italic>\n                       = 0.005), but no other lung function measures or TRACK score.\n                    </jats:p>\n                    <jats:p>\n                      68/73 (93%) children were followed up at 3 months. 29/68 (43%) children had &gt; 1 wheeze attack requiring unscheduled healthcare attendance. Absolute and %eosinophils at the baseline visit were higher in those who had an attack (median 0.5 × 10\n                      <jats:sup>9</jats:sup>\n                      /L vs. 0.3 × 10\n                      <jats:sup>9</jats:sup>\n                      /L,\n                      <jats:italic>p</jats:italic>\n                       = 0.03 and median 6% vs. 4%,\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.01). The DT model showed children with BEC ≥ 4% and TRACK score &lt; 75 were more likely to have a future attack (probability 0.63).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>POC blood eosinophils were feasible in a clinical setting. Our preliminary data suggest elevated BEC with a low symptom score predicts a wheeze attack within 3 months.</jats:p>\n                  </jats:sec>","journal":"Allergy","year":2025,"id":646589,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":862789,"name":"Sara Fontanella","orcid":"0000-0003-1681-9873","position":1,"is_corresponding":false},{"id":1684248,"name":"Hernani Almeida","orcid":null,"position":2,"is_corresponding":false},{"id":1684250,"name":"Barbara Pavlou","orcid":null,"position":3,"is_corresponding":false},{"id":1684252,"name":"Katariina Lajunen","orcid":null,"position":4,"is_corresponding":false},{"id":1684253,"name":"Samantha Irving","orcid":null,"position":5,"is_corresponding":false},{"id":241973,"name":"Ilaria Testa","orcid":"0000-0003-4005-4997","position":6,"is_corresponding":false},{"id":1684254,"name":"Yvonne Bingham","orcid":null,"position":7,"is_corresponding":false},{"id":1684255,"name":"Karina Mayoral Oritz","orcid":"0000-0002-7904-4422","position":8,"is_corresponding":false},{"id":1684256,"name":"Shane Lacbay","orcid":null,"position":9,"is_corresponding":false},{"id":1684257,"name":"Sophie Hay","orcid":null,"position":10,"is_corresponding":false},{"id":1684258,"name":"Mindy Gore","orcid":null,"position":11,"is_corresponding":false},{"id":1684259,"name":"Elizabeth Scotney","orcid":"0000-0002-9264-4174","position":12,"is_corresponding":false},{"id":1684260,"name":"Emmanouil Paraskakis","orcid":null,"position":13,"is_corresponding":false},{"id":1684262,"name":"Samatha Sonnappa","orcid":"0000-0002-9189-223X","position":14,"is_corresponding":false},{"id":911632,"name":"Louise Fleming","orcid":"0000-0002-7268-7433","position":15,"is_corresponding":false},{"id":542959,"name":"Andrew Bush","orcid":"0000-0001-6756-9822","position":16,"is_corresponding":false},{"id":690852,"name":"Sejal Saglani","orcid":"0000-0001-5192-6418","position":17,"is_corresponding":false},{"id":1684246,"name":"Kushalinii Hillson","orcid":"0000-0002-2675-288X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Point‐of‐Care Blood Eosinophils to Predict Preschool Wheeze Attacks","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:sec>\n                    <jats:title>Background</jats:title>\n                    <jats:p>Post hoc analysis of clinical trials shows blood eosinophil counts (BEC) predict future preschool wheeze attacks; however, prospective usefulness in a clinical setting is unreported. We assessed the feasibility of point‐of‐care (POC) eosinophil measurements in preschool wheezers and related BEC to symptoms, lung function, and utility in predicting attacks.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Children aged 1–5 years with recurrent wheeze underwent finger‐prick sampling during the outpatient clinic for POC eosinophils, forced oscillation technique (FOT) and/or spirometry, and symptom score (TRACK questionnaire). The utility of BEC and/or the other tests in predicting wheeze attacks in the subsequent 3 months was analysed by comparing those with and without an attack and using a predictive decision tree (DT) model.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      Seventy‐three children (median age 4.27 years) were recruited; BEC were higher in atopic children (median 0.5 × 10\n                      <jats:sup>9</jats:sup>\n                      /L vs. 0.3 × 10\n                      <jats:sup>9</jats:sup>\n                      /L non‐atopic,\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.01). BEC moderately correlated with FOT reactance bronchodilator reversibility\n                      <jats:italic>z</jats:italic>\n                      ‐score changes (\n                      <jats:italic>r</jats:italic>\n                       = 0.495,\n                      <jats:italic>p</jats:italic>\n                       = 0.005), but no other lung function measures or TRACK score.\n                    </jats:p>\n                    <jats:p>\n                      68/73 (93%) children were followed up at 3 months. 29/68 (43%) children had &gt; 1 wheeze attack requiring unscheduled healthcare attendance. Absolute and %eosinophils at the baseline visit were higher in those who had an attack (median 0.5 × 10\n                      <jats:sup>9</jats:sup>\n                      /L vs. 0.3 × 10\n                      <jats:sup>9</jats:sup>\n                      /L,\n                      <jats:italic>p</jats:italic>\n                       = 0.03 and median 6% vs. 4%,\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.01). The DT model showed children with BEC ≥ 4% and TRACK score &lt; 75 were more likely to have a future attack (probability 0.63).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>POC blood eosinophils were feasible in a clinical setting. Our preliminary data suggest elevated BEC with a low symptom score predicts a wheeze attack within 3 months.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39976168","pmcid":"PMC11969302","openalex_id":null,"authors":[],"funders":[{"funder_name":"Action Medical Research","grant_id":"","title":null},{"funder_name":"Masonic Charitable Foundation","grant_id":"","title":null},{"funder_name":"NIHR Imperial Biomedical Research Centre","grant_id":"","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.16500","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.16500","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/all.16500","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11969302","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11969302","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11969302?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Eosinophils","Humans","Asthma","Respiratory Sounds","Leukocyte Count","Prognosis","Prospective Studies","Child, Preschool","Infant","Point-of-Care Systems","Female","Male"],"keywords":["Biomarker","Risk factor","eosinophils","Machine Learning","Preschool Wheeze","Point‐Of‐Care Test","Wheeze Attacks"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T13:57:36.563939Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}