{"doi":"10.1111/ajt.16388","title":"Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study","abstract":"We undertook a prospective, matched cohort study of patients with Staphylococcus aureus bacteremia (SAB) and gram-negative bacteremia (GNB) to compare the characteristics, outcomes, and chemokine and cytokine response in transplant recipients to immunocompetent, nontransplant recipients. Fifty-five transplant recipients (GNB n = 29; SAB n = 26) and 225 nontransplant recipients (GNB n = 114; SAB n = 111) were included for clinical analysis. Transplant GNB had a significantly lower incidence of septic shock than nontransplant GNB (10.3% vs 30.7%, p = .03). Thirty-day mortality did not differ significantly between transplant and nontransplant recipients with GNB (10.3% vs 15.8%, p = .57) or SAB (0.0% vs 11.7%, p = .13). Next, transplant patients were matched 1:1 with nontransplant patients for the chemokine and cytokine analysis. Five cytokines and chemokines were significantly lower in transplant GNB vs nontransplant GNB: IL-2 (median [IQR]: 7.1 pg/ml [7.1, 7.1] vs 32.6 pg/ml [7.1, 88.0]; p = .001), MIP-1β (30.7 pg/ml [30.7, 30.7] vs 243.3 pg/ml [30.7, 344.4]; p = .001), IL-8 (32.0 pg/ml [5.6, 53.1] vs 59.1 pg/ml [39.2, 119.4]; p = .003), IL-15 (12.0 pg/ml [12.0, 12.0] vs 12.0 pg/ml [12.0, 126.7]; p = .03), and IFN-α (5.1 pg/mL [5.1, 5.1] vs 5.1 pg/ml [5.1, 26.3]; p = .04). Regulated upon Activation, Normal T Cell Expressed and Secreted (RANTES) was higher in transplant SAB vs nontransplant SAB (mean [SD]: 750.2 pg/ml [194.6] vs 656.5 pg/ml [147.6]; p = .046).","journal":"American Journal of Transplantation","year":2020,"id":71789,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8071,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":37805,"name":"Felicia Ruffin","orcid":"0000-0003-2176-6462","position":1,"is_corresponding":false},{"id":331148,"name":"Michael Dagher","orcid":"0000-0002-4305-9294","position":2,"is_corresponding":false},{"id":379019,"name":"Reginald Lerebours","orcid":"0000-0003-2884-3168","position":3,"is_corresponding":false},{"id":374167,"name":"Sin‐Ho Jung","orcid":"0000-0002-1473-7236","position":4,"is_corresponding":false},{"id":331149,"name":"Batu K. Sharma‐Kuinkel","orcid":"0000-0002-7217-3213","position":5,"is_corresponding":false},{"id":225650,"name":"Andrew N. Macintyre","orcid":"0000-0002-5297-0207","position":6,"is_corresponding":false},{"id":302598,"name":"Joshua T. Thaden","orcid":"0000-0002-3250-0697","position":7,"is_corresponding":false},{"id":379020,"name":"Matthew R. Sinclair","orcid":"0000-0002-8003-9786","position":8,"is_corresponding":false},{"id":286181,"name":"Lauren Hale","orcid":"0000-0002-2574-2225","position":9,"is_corresponding":false},{"id":331152,"name":"Celia Kohler","orcid":"0000-0002-8517-4012","position":10,"is_corresponding":false},{"id":278245,"name":"Scott M. Palmer","orcid":"0000-0002-1370-3771","position":11,"is_corresponding":false},{"id":379021,"name":"Barbara D. Alexander","orcid":"0000-0001-5868-0529","position":12,"is_corresponding":false},{"id":32929,"name":"Vance G. Fowler","orcid":"0000-0002-8048-0897","position":13,"is_corresponding":false},{"id":319847,"name":"Stacey A. Maskarinec","orcid":"0000-0002-1716-8374","position":14,"is_corresponding":false},{"id":319849,"name":"Emily M. Eichenberger","orcid":"0000-0002-2469-0638","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T21:44:25.469842Z","pmid":"33131212","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}